Ex vivo MR imaging of colorectal carcinoma before and after formalin fixation: correlation with histopathologic findings
Sign Up to like & getrecommendations! Published in 2018 at "Abdominal Radiology"
DOI: 10.1007/s00261-018-1538-8
Abstract: PurposeWe aimed to assess and compare ex vivo MRI of resected colorectal carcinoma before and after formalin fixation.MethodsWe enrolled 45 consecutive patients (47 carcinomas) who underwent colorectal carcinoma surgery. Specimens underwent two MR scans at… read more here.
Keywords: formalin fixation; fixation; colorectal carcinoma; carcinoma formalin ... See more keywords
Be bold, start cold! cold formalin fixation of colorectal cancer specimens granted superior DNA and RNA quality for downstream molecular analysis
Sign Up to like & getrecommendations! Published in 2024 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-024-02326-5
Abstract: The use of cold formalin fixation (CFF; i.e., fixating tissue samples with 4 °C precooled formalin) recently attracted further attention owing to its putative improved ability to preserve nucleic acid compared with standard room temperature… read more here.
Keywords: dna rna; formalin; cold formalin; formalin fixation ... See more keywords
Formalin Fixation and Cryosectioning Cause Only Minimal Changes in Shape or Size of Ocular Tissues
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12006-1
Abstract: Advances in imaging have made it increasingly common to study soft tissues without first embedding them in plastic or paraffin and without using labels or stains. The process, however, usually still involves fixation and cryosectioning,… read more here.
Keywords: formalin fixation; ocular tissues; fixation; minimal changes ... See more keywords
Examining the Formalin Fixation Method for Maintaining High RNA Quality in Surgical Lung Specimens
Sign Up to like & getrecommendations! Published in 2025 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.70005
Abstract: Multiplex genetic testing is recommended when treating nonsmall cell lung cancer. A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure is a possible… read more here.
Keywords: quality; lung; examining formalin; rna ... See more keywords
Effect of formalin fixation on measured concentrations of deposited gadolinium in human tissue: an autopsy study.
Sign Up to like & getrecommendations! Published in 2021 at "Acta radiologica"
DOI: 10.1177/0284185121994047
Abstract: BACKGROUND Generally, studies of gadolinium (Gd) deposition in humans measure concentration by analyzing formalin fixed postmortem tissue. However, the effect of formalin fixation on measured Gd concentration has not been well investigated. PURPOSE To evaluate… read more here.
Keywords: formalin fixation; fixation; tissue; effect ... See more keywords
Formalin fixation on HER-2 and PD-L1 expression in gastric cancer: A pilot analysis using the same surgical specimens with different fixation times
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Clinical Cases"
DOI: 10.12998/wjcc.v7.i4.419
Abstract: BACKGROUND The needs for human epidermal growth factor receptor 2 (HER-2) and/or programmed death-ligand 1 (PD-L1) evaluations in gastric cancer are dramatically increasing. Although the importance of standardization of sample fixation has been widely recognized,… read more here.
Keywords: formalin fixation; fixation; gastric cancer; fixation expression ... See more keywords
Cold Formalin Fixation Guarantees DNA Integrity in Formalin Fixed Paraffin Embedded Tissues: Premises for a Better Quality of Diagnostic and Experimental Pathology With a Specific Impact on Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00173
Abstract: Formalin fixation and paraffin embedding (FFPE) represent the standard method to preserve tissue specimens for diagnostic pathology, however formalin fixation induces severe fragmentation of nucleic acids. We investigated whether formalin fixation at 4°C could preserve… read more here.
Keywords: formalin fixation; dna integrity; fixation; pathology ... See more keywords
Oral Squamous Cell Carcinoma and What We Lose During Formalin Fixation: An Evaluation of Changes in Macroscopic Resection Margins Utilizing Virtual Three-Dimensional Imaging Techniques with Analysis Based on 947 Measurements
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12122805
Abstract: Background: An adequate OSCC macroscopic resection margin (MRM) is essential for effective treatment. This study analyzed the effects of formalin fixation (FF) on the MRM. Material and Methods: A total of 42 patients were enrolled… read more here.
Keywords: analysis; macroscopic resection; shrinkage; formalin fixation ... See more keywords
Anti-Shrinkage Technique for Feline Skin Samples
Sign Up to like & getrecommendations! Published in 2024 at "Veterinary Sciences"
DOI: 10.3390/vetsci11100507
Abstract: Simple Summary Complete surgical removal of a subcutaneous tumor and its margin evaluation are crucial for preventing local recurrence and avoiding further treatments. However, surgical margins often differ from those identified during histopathological evaluation due… read more here.
Keywords: formalin fixation; shrinkage; feline skin; technique ... See more keywords