Blockade of the orexin receptors in the CA1 region of hippocampus decreased the lateral hypothalamic-induced antinociceptive responses in the model of orofacial formalin test in the rats
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2017.10.006
Abstract: HighlightsA pathway from the lateral hypothalamus to CA1 modulates early (0–3 min) and late phases (15–33 min) of formalin‐induced orofacial nociception.Blockade of CA1 orexin receptors (OXRs) reduced LH‐induced antinociception during the early and late phases… read more here.
Keywords: orexin receptors; orofacial formalin; ca1; late phases ... See more keywords
Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.1016/j.peptides.2021.170679
Abstract: Stress activates multiple neural pathways and neurotransmitters that often suppress pain perception, the phenomenon called stress-induced analgesia (SIA). Orexin neurons from the lateral hypothalamus project to entire brain structures such as the hippocampus. The present… read more here.
Keywords: region hippocampus; ca1 region; stress induced; formalin test ... See more keywords
The role of L-arginine/NO/cGMP/KATP channel pathway in the local antinociceptive effect of berberine in the rat formalin test.
Sign Up to like & getrecommendations! Published in 2023 at "Behavioural pharmacology"
DOI: 10.1097/fbp.0000000000000721
Abstract: Berberine is an isoquinoline alkaloid naturally produced by several types of plants. Berberine has extensive pharmacological effects, such as anti-diabetic, anti-inflammatory, and antioxidant effects. In the current study, we assess the antinociceptive effects of berberine… read more here.
Keywords: cgmp katp; formalin test; paw; berberine ... See more keywords
The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin
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DOI: 10.14814/phy2.15194
Abstract: The most widely used formalin test to screen antinociceptive drug candidates is still apostrophized as targeting inflammatory pain, in spite of strong opposing evidence published. In our rat skin‐nerve preparation ex vivo, recording from all… read more here.
Keywords: nerve; inflammatory pain; formalin test;
Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions
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DOI: 10.3390/pharmaceutics14051006
Abstract: The essential oil of bergamot (BEO) has consistently proven antinociceptive and antiallodynic properties. Accordingly, the analgesic efficacy of the decolored essential oil (DEC), with higher levels of limonene, and the deterpenated (DET) fraction, with higher… read more here.
Keywords: oil; transdermal administration; essential oil; formalin test ... See more keywords
Differential Antinociceptive Efficacy of Peel Extracts and Lyophilized Juices of Three Varieties of Mexican Pomegranate (Punica granatum L.) in the Formalin Test
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DOI: 10.3390/plants12010131
Abstract: Pharmacological treatment of pain often causes undesirable effects, so it is necessary to look for natural, safe, and effective alternatives to alleviate painful behavior. In this context, it is known that different parts of pomegranate… read more here.
Keywords: lyophilized juices; juices three; antinociceptive effect; formalin test ... See more keywords
Effects of Salmon Calcitonin on the Concentrations of Monoamines in Periaqueductal Gray in Formalin Test
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DOI: 10.4274/balkanmedj.galenos.2019.2018.12.88
Abstract: Background: The receptors of salmon calcitonin, located on certain areas of the brain such as the periaqueductal gray matter, are responsible for pain modulation. Aims: The effects of intracerebroventricular injection of salmon calcitonin on the… read more here.
Keywords: periaqueductal gray; salmon calcitonin; formalin test; pain ... See more keywords