Copper(I) halide-promoted formation of 3-acyl-5-halopyridine moiety from NH-2-(2-acylethynyl)pyrroles and propargylamine
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DOI: 10.1016/j.mencom.2019.05.003
Abstract: Available NH-2-acylethynylpyrroles undergo annulation/aromatization with propargylamine in the presence of 1 equiv. of CuHal (Hal = Cl, Br, I) at 60–65 °C to afford 3-acyl-2-(pyrrol-2-yl)pyridines and their 5-halo analogues in 28–61 and 5–14% yields, respectively. The latter are… read more here.
Keywords: formation acyl; promoted formation; halide promoted; copper halide ... See more keywords