Eduscho Coffee Extract Effectively Inhibits the Formation of Amyloid-like Fibrils by Trypsin in Aqueous Ethanol
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DOI: 10.1177/1934578x1801301229
Abstract: In this work we used an in vitro trypsin aggregation model to show that certain commercial coffee extracts can inhibit protein aggregation. Aggregation experiments were performed using several spectroscopic methods and a dye binding assay,… read more here.
Keywords: eduscho coffee; formation amyloid; amyloid like; coffee extract ... See more keywords
Indomethacin Disrupts the Formation of β-Amyloid Plaques via an α2-Macroglobulin-Activating lrp1-Dependent Mechanism
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DOI: 10.3390/ijms22158185
Abstract: Epidemiological studies have implied that the nonsteroidal anti-inflammatory drug (NSAID) indomethacin slows the development and progression of Alzheimer’s disease (AD). However, the underlying mechanisms are notably understudied. Using a chimeric mouse/human amyloid precursor protein (Mo/HuAPP695swe)… read more here.
Keywords: disrupts formation; formation amyloid; dependent mechanism; indomethacin ... See more keywords
Oligomer Formation by Amyloid-β42 in a Membrane-Mimicking Environment in Alzheimer’s Disease
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DOI: 10.3390/molecules27248804
Abstract: The brains of Alzheimer’s disease (AD) patients contain numerous amyloid plaques that are diagnostic of the disease. The plaques are primarily composed of the amyloidogenic peptides proteins Aβ40 and Aβ42, which are derived by the… read more here.
Keywords: membrane mimicking; disease; alzheimer disease; amyloid membrane ... See more keywords