Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification.
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DOI: 10.1016/j.taap.2021.115553
Abstract: p-Cresol sulfate, the primary metabolite of p-cresol, is a uremic toxin that has been associated with toxicities and mortalities. The study objectives were to i) characterize the contributions of human sulfotransferases (SULT) catalyzing p-cresol sulfate… read more here.
Keywords: mefenamic acid; formation cresol; cresol sulfate; cresol ... See more keywords