Differential Effects of Aromatic Residues on Amyloid Formation and Cytotoxicity of Human IAPP.
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DOI: 10.1021/acs.biochem.2c00267
Abstract: Islet amyloid polypeptide (IAPP) is a 37-residue polypeptide hormone secreted by the pancreatic β-cells. IAPP plays a role in glycemic regulation, but in the pre-type-2 diabetic state, it aggregates to form an islet amyloid. The… read more here.
Keywords: amyloid formation; aromatic residues; role; formation cytotoxicity ... See more keywords