Neutralizing Mutations Significantly Inhibit Amyloid Formation by Human Prion Protein and Decrease Its Cytotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.11.020
Abstract: Prion diseases, such as Creutzfeldt-Jakob disease and bovine spongiform encephalopathy, are fatal neurodegenerative diseases that affect many mammals including humans, and are caused by the misfolding of prion protein (PrP). A naturally occurring protective polymorphism… read more here.
Keywords: formation human; neutralizing mutations; prion; formation ... See more keywords
Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures
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DOI: 10.1038/s41598-018-27504-z
Abstract: Biofilms are major contributors to delayed wound healing and there is a need for clinically relevant experimental models to assess theranostics. Microorganisms release volatile organic compounds (VOCs) and the ability to identify these in infected… read more here.
Keywords: formation human; wound; biofilm formation; biofilm ... See more keywords
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung
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DOI: 10.1093/carcin/bgy065
Abstract: Abstract 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL)… read more here.
Keywords: reductase; formation human; human lung; nnal formation ... See more keywords