Artery formation in the intestinal wall and mesentery by intestine-derived Esm1+ endothelial cells
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64047-0
Abstract: Arterial blood transport into peripheral organs is indispensable for developmental growth, homeostasis and tissue repair. While it is appreciated that defective formation or compromised function of arteries is associated with a range of human diseases,… read more here.
Keywords: artery formation; formation intestinal; intestinal wall; endothelial cells ... See more keywords
Covalent CES2 Inhibitors Protect against Reduced Formation of Intestinal Organoids by the Anticancer Drug Irinotecan.
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DOI: 10.2174/1389200224666221212143904
Abstract: BACKGROUND Irinotecan is widely used to treat various types of solid and metastatic cancer. It is an ester prodrug and its hydrolytic metabolite (SN-38) exerts potent anticancer activity. Irinotecan is hydrolyzed primarily by carboxylesterase-2 (CES2),… read more here.
Keywords: covalent ces2; ces2; reduced formation; formation intestinal ... See more keywords