Role of formin INF2 in human diseases.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06869-x
Abstract: Formin proteins catalyze actin nucleation and microfilament polymerization. Inverted formin 2 (INF2) is an atypical diaphanous-related formin characterized by polymerization and depolymerization of actin. Accumulating evidence showed that INF2 is associated with kidney disease focal… read more here.
Keywords: inf2 human; biology; formin; human diseases ... See more keywords
FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2016.12.004
Abstract: Abstract The functional properties of actin‐regulating formin proteins are diverse and in many cases cell‐type specific. FHOD1, a formin expressed predominantly in cells of mesenchymal lineage, bundles actin filaments and participates in maintenance of cell… read more here.
Keywords: fhod1 formin; cell; formin; tumor growth ... See more keywords
Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00445-3
Abstract: Cytokinesis physically separates dividing cells by forming a contractile actomyosin ring. The fission yeast contractile ring has been proposed to assemble by Search-Capture-Pull-Release from cytokinesis precursor nodes that include the molecular motor type-II myosin Myo2… read more here.
Keywords: ring assembly; actomyosin ring; contractile actomyosin; formin ... See more keywords
The neuron-specific formin Delphilin nucleates nonmuscle actin but does not enhance elongation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-06-0363
Abstract: The formin Delphilin binds the glutamate receptor, GluRδ2, in dendritic spines of Purkinje cells. Both proteins play a role in learning. To understand how Delphilin functions in neurons, we studied the actin assembly properties of… read more here.
Keywords: nonmuscle actin; elongation; formin delphilin; formin ... See more keywords
Dual control of formin-nucleated actin assembly by the chromatin and ER in mouse oocytes
Sign Up to like & getrecommendations! Published in 2022 at "Current Biology"
DOI: 10.2139/ssrn.4075229
Abstract: The first asymmetric meiotic cell divisions in mouse oocytes are driven by formin 2 (FMN2)-nucleated actin polymerization around the spindle. In this study, we investigated how FMN2 is recruited to the spindle peripheral ER and… read more here.
Keywords: formin; mouse oocytes; control formin; nucleated actin ... See more keywords
Investigating Mammalian Formins with SMIFH2 Fifteen Years in: Novel Targets and Unexpected Biology
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24109058
Abstract: The mammalian formin family comprises fifteen multi-domain proteins that regulate actin dynamics and microtubules in vitro and in cells. Evolutionarily conserved formin homology (FH) 1 and 2 domains allow formins to locally modulate the cell… read more here.
Keywords: investigating mammalian; formin; formins smifh2; smifh2 fifteen ... See more keywords
Modulation of formin processivity by profilin and mechanical tension
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.34176
Abstract: Formins are major regulators of actin networks. They enhance actin filament dynamics by remaining processively bound to filament barbed ends. How biochemical and mechanical factors affect formin processivity are open questions. Monitoring individual actin filaments… read more here.
Keywords: tension; formin processivity; formin dissociation; formin ... See more keywords