Ancestral Sequence Reconstruction of the Ethylene-Forming Enzyme
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DOI: 10.1021/acs.biochem.5c00334
Abstract: The ethylene-forming enzyme (EFE) catalyzes two main reactions: the conversion of 2-oxoglutarate (2OG) to ethylene plus CO2 and the oxidative decarboxylation of 2OG coupled to the C5 hydroxylation of l-arginine (l-Arg). EFE also facilitates two… read more here.
Keywords: reconstruction ethylene; forming enzyme; ancestral sequence; arg ... See more keywords
Thermodynamics of Iron(II) and Substrate Binding to the Ethylene-Forming Enzyme.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00730
Abstract: The ethylene-forming enzyme (EFE), like many other 2-oxoglutarate (2OG)-dependent nonheme iron(II) oxygenases, catalyzes the oxidative decarboxylation of 2OG to succinate and CO2 to generate a highly reactive iron species that hydroxylates a specific alkane C-H… read more here.
Keywords: ethylene forming; ethylene; thermodynamics; thermodynamics iron ... See more keywords
Experimental Evidence for Radical-Polar Crossover in Competition with, Rather Than Preceding, Alkene Formation by Microbial Ethylene-Forming Enzyme.
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DOI: 10.1021/jacs.5c13787
Abstract: Ethylene-forming enzyme (EFE) catalyzes a reaction that sets it apart from other iron(II)- and 2-oxoglutarate-dependent (Fe/2OG) oxygenases. In this reaction, all four oxidizing equivalents of O2 are unleashed upon 2OG, fragmenting it to ethylene (from… read more here.
Keywords: ethylene; polar crossover; radical polar; ethylene forming ... See more keywords
Structures and Mechanisms of the Non-Heme Fe(II)- and 2-Oxoglutarate-Dependent Ethylene-Forming Enzyme: Substrate Binding Creates a Twist.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b06186
Abstract: The ethylene-forming enzyme (EFE) from Pseudomonas syringae pv. phaseolicola PK2 is a member of the mononuclear nonheme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase superfamily. EFE converts 2OG into ethylene plus three CO2 molecules while also catalyzing… read more here.
Keywords: ethylene forming; ethylene; substrate binding; oxoglutarate ... See more keywords
N6-methyladenosine (m6A)-forming enzyme METTL3 controls UAF1 stability to promote inflammation in a model of colitis by stimulating NLRP3
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DOI: 10.1038/s41598-025-88435-0
Abstract: The rising incidence of ulcerative colitis (UC) in China poses a noticeable health challenge. This study aimed to assess the pivotal role of USP1-associated factor 1 (UAF1) in colitis. UC was induced in male C57BL/6… read more here.
Keywords: m6a forming; model; inflammation; expression ... See more keywords