Effects of Injection Volume and Route of Administration on Dolutegravir In Situ Forming Implant Pharmacokinetics
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DOI: 10.3390/pharmaceutics14030615
Abstract: Due to the versatility of the in situ forming implant (ISFI) drug delivery system, it is crucial to understand the effects of formulation parameters for clinical translation. We utilized ultrasound imaging and pharmacokinetics (PK) in… read more here.
Keywords: injection; forming implant; administration; situ forming ... See more keywords
Dose-Ranging Plasma and Genital Tissue Pharmacokinetics and Biodegradation of Ultra-Long-Acting Cabotegravir In Situ Forming Implant
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DOI: 10.3390/pharmaceutics15051487
Abstract: HIV continues to affect millions of men and women worldwide. The development of long-acting injectables for HIV prevention can overcome adherence challenges with daily oral prevention regimens by reducing dosing frequency and stigma. We previously… read more here.
Keywords: forming implant; situ forming; ultra long; genital tissue ... See more keywords