γ‐(S)‐Guanidinylmethyl‐Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake
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DOI: 10.1002/cbic.201900393
Abstract: γ‐Modified (i.e., (S)‐aminomethyl, (S)‐acetamidomethyl, (R)‐4‐(hydroxymethyl)triazol‐1‐ylmethyl, and (S)‐guanidinylmethyl) triplex‐forming peptide nucleic acids (TFPNAs) were synthesized and the effect of the backbone modifications on the binding to a miR‐215 model was studied. Among the modifications, an appropriate… read more here.
Keywords: nucleic acids; peptide nucleic; guanidinylmethyl; forming peptide ... See more keywords