Distribution and Structure Analysis of Fibril-Forming Peptides Focusing on Concentration Dependency
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DOI: 10.1021/acsomega.1c04960
Abstract: We focus on the concentration dependency of fibril-forming peptides, which have the potential of aggregation by themselves. In this study, we performed replica-exchange molecular dynamics simulations of Lys-Phe-Phe-Glu (KFFE) fragments, which are known to form… read more here.
Keywords: structure; fibril forming; concentration; forming peptides ... See more keywords
From Hydrogel to Crystal: A Molecular Design Strategy that Chemically Modifies Racemic Gel-Forming Peptides to Furnish Crystalline Fibrils Stabilized by Parallel Rippled β-Sheets.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c00671
Abstract: Rippled β-sheets are an underutilized secondary structural motif that hold promise in the rational design of peptide hydrogel materials with unique and desirable properties. Fully capitalizing on the design potential of this structural element, however,… read more here.
Keywords: gel forming; rippled sheets; molecular design; design strategy ... See more keywords
An active machine learning discovery platform for membrane-disrupting and pore-forming peptides
Sign Up to like & getrecommendations! Published in 2024 at "Physical Chemistry Chemical Physics"
DOI: 10.1039/d4cp01404a
Abstract: Membrane-disrupting and pore-forming peptides (PFPs) play a substantial role in bionanotechnology and can determine the life and death of cells. The control of chemical and ion transport through cell membranes is essential to maintaining concentration… read more here.
Keywords: membrane disrupting; pore forming; disrupting pore; forming peptides ... See more keywords
On the Conformational Dynamics of β-Amyloid Forming Peptides: A Computational Perspective
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DOI: 10.3389/fbioe.2020.00532
Abstract: Understanding the conformational dynamics of proteins and peptides involved in important functions is still a difficult task in computational structural biology. Because such conformational transitions in β-amyloid (Aβ) forming peptides play a crucial role in… read more here.
Keywords: forming peptides; conformational dynamics; peptides computational; dynamics amyloid ... See more keywords