Analyses of viral genomes for G-quadruplex forming sequences reveal their correlation with the type of infection.
Sign Up to like & getrecommendations! Published in 2021 at "Biochimie"
DOI: 10.1016/j.biochi.2021.03.017
Abstract: G-quadruplexes contribute to the regulation of key molecular processes. Their utilization for antiviral therapy is an emerging field of contemporary research. Here we present comprehensive analyses of the presence and localization of putative G-quadruplex forming… read more here.
Keywords: infection; analyses viral; type; viral genomes ... See more keywords
Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters
Sign Up to like & getrecommendations! Published in 2018 at "ACS Omega"
DOI: 10.1021/acsomega.8b01551
Abstract: We have studied the in vitro stability of 25 potential i-motif-forming DNA sequences found within the promoter regions of 18 different human DNA repair genes. Three widely available methods of characterization were used to rapidly… read more here.
Keywords: motif; potential motif; motif forming; dna repair ... See more keywords
R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63101-9
Abstract: R-loops are RNA-DNA hybrid sequences that are emerging players in various biological processes, occurring in both prokaryotic and eukaryotic cells. In viruses, R-loop investigation is limited and functional importance is poorly understood. Here, we performed… read more here.
Keywords: analysis; loop forming; sequences analysis; viral genomes ... See more keywords
G-Quadruplexes in the Archaea Domain
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10091349
Abstract: The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and… read more here.
Keywords: archaea domain; presence; dna; quadruplexes archaea ... See more keywords
Tracing dsDNA Virus–Host Coevolution through Correlation of Their G-Quadruplex-Forming Sequences
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073433
Abstract: The importance of gene expression regulation in viruses based upon G-quadruplex may point to its potential utilization in therapeutic targeting. Here, we present analyses as to the occurrence of putative G-quadruplex-forming sequences (PQS) in all… read more here.
Keywords: pqs; host; virus host; quadruplex forming ... See more keywords