Inflammasome activation by Pseudomonas aeruginosa's ExlA pore‐forming toxin is detrimental for the host
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DOI: 10.1111/cmi.13251
Abstract: During acute Pseudomonas aeruginosa infection, the inflammatory response is essential for bacterial clearance. Neutrophil recruitment can be initiated following the assembly of an inflammasome within sentinel macrophages, leading to activation of caspase‐1, which in turn… read more here.
Keywords: pseudomonas aeruginosa; inflammasome activation; forming toxin; pore forming ... See more keywords
When the Phagosome Gets Leaky: Pore-Forming Toxin-Induced Non-Canonical Autophagy (PINCA)
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DOI: 10.3389/fcimb.2022.834321
Abstract: Macrophages remove bacteria from the extracellular milieu via phagocytosis. While most of the engulfed bacteria are degraded in the antimicrobial environment of the phagolysosome, several bacterial pathogens have evolved virulence factors, which evade degradation or… read more here.
Keywords: pore forming; canonical autophagy; pinca; non canonical ... See more keywords
ExlA Pore-Forming Toxin: Localization at the Bacterial Membrane, Regulation of Secretion by Cyclic-Di-GMP, and Detection In Vivo
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DOI: 10.3390/toxins13090645
Abstract: ExlA is a highly virulent pore-forming toxin that has been recently discovered in outlier strains from Pseudomonas aeruginosa. ExlA is part of a two-partner secretion system, in which ExlA is the secreted passenger protein and… read more here.
Keywords: secretion; exla; gmp; forming toxin ... See more keywords