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Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2580
Abstract: While studies have demonstrated substantial differences in beta2 -adrenergic agonist enantiomer pharmacology, enantioselective disposition of long-acting beta2 -adrenergic ligand racemic (rac)-formoterol in blood is inadequately explored after inhaled therapy given analytical challenges. Furthermore, information on…
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Keywords:
skeletal muscle;
formoterol;
beta2 adrenergic;
enantioselective disposition ... See more keywords
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Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01224-8
Abstract: The inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fluticasone propionate/formoterol fumarate (FP/FORM; Flutiform®) has been available as fixed-dose combination (FDC) therapy for asthma patients aged ≥ 12 years in the UK since 2012. This post-authorisation safety study examined adverse…
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Keywords:
formoterol;
fdc ics;
study;
form ... See more keywords
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Published in 2019 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2019.03.007
Abstract: PURPOSE The objective of this study was to assess pharmacokinetic (PK) and safety profiles of 2 fixed-dose combinations in development for the treatment of chronic obstructive pulmonary disease (COPD): budesonide/glycopyrronium/formoterol fumarate dihydrate metered-dose inhaler (BGF…
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Keywords:
formoterol;
fumarate dihydrate;
glycopyrronium;
formoterol fumarate ... See more keywords
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Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.03.023
Abstract: Podocytes have limited ability to recover from injury. Here, we demonstrate that increased mitochondrial biogenesis, to meet the metabolic and energy demand of a cell, accelerates podocyte recovery from injury. Analysis of events induced during…
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Keywords:
mitochondrial biogenesis;
formoterol;
biogenesis;
injury ... See more keywords
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Published in 2019 at "Expert Review of Respiratory Medicine"
DOI: 10.1080/17476348.2019.1665514
Abstract: ABSTRACT Introduction: Inhaled corticosteroid (ICS) plus long-acting β2-agonist (LABA) combinations are commonly used in the treatment of patients with chronic obstructive pulmonary disease (COPD). At least four fixed-dose ICS/LABA combinations are available, including budesonide/formoterol, beclomethasone/formoterol,…
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Keywords:
formoterol;
long acting;
inhaled corticosteroid;
plus long ... See more keywords
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Published in 2023 at "Journal of aerosol medicine and pulmonary drug delivery"
DOI: 10.1089/jamp.2022.0064
Abstract: Introduction: Fluticasone propionate/formoterol fumarate (fluticasone/formoterol) exposures, following administration of Flutiform® K-haler®, a breath-actuated inhaler (BAI), were compared with the Flutiform pressurized metered-dose inhaler (pMDI) with/without spacer in two healthy volunteer studies. In addition, formoterol-induced systemic…
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Keywords:
inhaler;
pmdi;
formoterol;
bai ... See more keywords
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Published in 2019 at "Journal of neurotrauma"
DOI: 10.1089/neu.2018.5669
Abstract: A hallmark of the progressive cascade of damage referred to as secondary spinal cord injury (SCI) is vascular disruption resulting in decreased oxygen delivery and loss of mitochondria homeostasis. While therapeutics targeting restoration of single…
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Keywords:
formoterol;
administration;
treatment;
injury ... See more keywords
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Published in 2021 at "Annals of Pharmacotherapy"
DOI: 10.1177/10600280211038353
Abstract: Objective: To review current evidence on the use of a fixed-dose combination (FDC) of budesonide/glycopyrrolate/formoterol fumarate (BGFF) triple therapy delivered via metered dose inhaler (MDI) in patients with chronic obstructive pulmonary disease (COPD) and offer…
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Keywords:
bgff mdi;
triple therapy;
therapy;
budesonide glycopyrrolate ... See more keywords
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Published in 2022 at "European Respiratory Journal"
DOI: 10.1183/13993003.02309-2021
Abstract: Background Our objective was to determine the comparative bronchodilator, systemic β2-agonist, cardiovascular and adverse effects of salbutamol 200 µg and budesonide/formoterol 200/6 µg when taken repeatedly in stable asthma. Methods This open-label, crossover, single-centre, controlled trial randomised…
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Keywords:
formoterol;
formoterol 200;
min;
salbutamol 200 ... See more keywords
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Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa610
Abstract: Introduction: GINA guidelines recognise the importance of correct inhaler technique and patient preference when individualising therapy. A novel BTI (Flutiform® K‑haler®) has been developed to deliver fluticasone propionate/formoterol (FP/FORM). Aims and Objectives: To investigate correct…
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Keywords:
formoterol;
form bti;
bti;
inhaler ... See more keywords
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Published in 2018 at "European Respiratory Journal"
DOI: 10.1183/13993003.congress-2018.pa688
Abstract: Objective: To assess the relationship of baseline eosinophil (EOS) levels with treatment responses to BGF MDI 320/14.4/10 µg (ICS/LAMA/LABA), glycopyrronium/formoterol [GFF] MDI 14.4/10 µg (LAMA/LABA) and budesonide/formoterol [BFF] MDI 320/10 µg (ICS/LABA). Methods: Pre-specified analysis…
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Keywords:
formoterol;
gff mdi;
bgf mdi;
mdi ... See more keywords