Optimization of liposomal topotecan for use in treating neuroblastoma
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DOI: 10.1002/cam4.1083
Abstract: The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited… read more here.
Keywords: topotecan use; formulation; drug; liposomal topotecan ... See more keywords
Effect of Colonic Absorption on the Pharmacokinetic Properties of Delayed‐Release and Extended‐Release Methylphenidate: In Vivo, In Vitro, and Modeling Evaluations
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DOI: 10.1002/cpdd.1089
Abstract: Most stimulants used to treat attention‐deficit/hyperactivity disorder are administered in the morning and absorbed in the upper gastrointestinal tract. DR/ER‐MPH (formerly HLD200), an evening‐dosed delayed‐release and extended‐release methylphenidate, is predicted to be absorbed in the… read more here.
Keywords: formulation; release; release methylphenidate; extended release ... See more keywords
Clinical Formulation Bridging of Gefapixant, a P2X3‐Receptor Antagonist, for the Treatment of Chronic Cough
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DOI: 10.1002/cpdd.1105
Abstract: Gefapixant is a P2X3‐receptor antagonist being developed for treatment of refractory or unexplained chronic cough. Four phase 1 studies were conducted in healthy participants that bridged the early‐phase gefapixant formulation (F01) to the phase 3… read more here.
Keywords: receptor antagonist; formulation; chronic cough; p2x3 receptor ... See more keywords
Effects of Tablet Formulation, Food, or Gastric pH on the Bioavailability of Asundexian
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DOI: 10.1002/cpdd.1207
Abstract: Absolute bioavailability (F) and the impact of gastric pH, tablet formulation, and food on the pharmacokinetics and safety of asundexian, an oral factor XIa inhibitor, was assessed in healthy White men aged 18–45 years in… read more here.
Keywords: tablet formulation; formulation; food; bioavailability ... See more keywords
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
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DOI: 10.1002/cpdd.1208
Abstract: This open‐label, randomized, 3‐treatment, 3‐period, 6‐sequence, crossover study in healthy subjects compared the pharmacokinetic and pharmacodynamic properties of a lipid‐based (soft gelatin capsule) prototype final market image (pFMI) formulation of tropifexor (90‐µg) to its clinical… read more here.
Keywords: formulation; csf; food; concentration ... See more keywords
Single‐Dose Pharmacokinetics of Oral Cannabidiol Following Administration of PTL101: A New Formulation Based on Gelatin Matrix Pellets Technology
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DOI: 10.1002/cpdd.408
Abstract: Cannabidiol (CBD) is the main nonpsychoactive component of the cannabis plant. It has been associated with antiseizure, antioxidant, neuroprotective, anxiolytic, anti‐inflammatory, antidepressant, and antipsychotic effects. PTL101 is an oral gelatin matrix pellets technology–based formulation containing… read more here.
Keywords: cbd; pellets technology; matrix pellets; formulation ... See more keywords
Pharmacokinetics and Bioequivalence Evaluation of Erlotinib Hydrochloride Tablets: Randomized, Open‐Label, 2‐Period Crossover Study in Healthy Chinese Subjects
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DOI: 10.1002/cpdd.811
Abstract: A randomized, open‐label, 2‐period crossover study was performed to evaluate the pharmacokinetic properties and bioequivalence of 2 erlotinib hydrochloride tablets (a test formulation and a reference formulation) in healthy Chinese subjects. Subjects were randomized to… read more here.
Keywords: bioequivalence; formulation; study; period ... See more keywords
Evaluation of Pharmacokinetics, Safety, and Drug‐Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults
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DOI: 10.1002/cpdd.925
Abstract: Intravenous (IV) edaravone is approved as an amyotrophic lateral sclerosis (ALS) treatment. Because IV administration places a burden on patients, development of orally administered ALS treatments is needed. Therefore, 2 phase 1 studies of oral… read more here.
Keywords: formulation; edaravone healthy; drug; edaravone ... See more keywords
Pharmacokinetics and Bioequivalence Study of a New Branded Generic Moxifloxacin Tablet Among Healthy Volunteers.
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DOI: 10.1002/cpdd.964
Abstract: A newly developed branded generic of a moxifloxacin (MOX) 400-mg tablet formulation was manufactured prior to this study. A bioequivalence (BE) study was done to assess the pharmacokinetics of the formulation using a randomized, open-label,… read more here.
Keywords: branded generic; formulation; generic moxifloxacin; bioequivalence study ... See more keywords
Process‐Structure‐Formulation Interactions for Enhanced Sodium Ion Battery Development: A Review
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DOI: 10.1002/cphc.202100860
Abstract: Abstract Before the viability of a cell formulation can be assessed for implementation in commercial sodium ion batteries, processes applied in cell production should be validated and optimized. This review summarizes the steps performed in… read more here.
Keywords: formulation; review; process structure; sodium ion ... See more keywords
Development of a nonconservative discontinuous Galerkin formulation for simulations of unsteady and turbulent flows
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DOI: 10.1002/fld.4785
Abstract: In this paper, discontinuous Galerkin (DG) discretization schemes for Navier‐Stokes equations of a nonconservative form was proposed, in which the constitutional equation for energy conservation is written in terms of pressure. The primary focus is… read more here.
Keywords: discontinuous galerkin; development nonconservative; nonconservative discontinuous; formulation ... See more keywords