Formulation-Based Cost Savings with Cabozantinib Capsules.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2025.0175
Abstract: This Viewpoint asserts that the formulation (tablet vs capsule) and the dosage of cabozantinib can be optimized to reduce toxicities and cost while maintaining efficacy. read more here.
Keywords: formulation; formulation based; based cost; cost savings ... See more keywords
Innovative Formulation Platform: Paving the Way for Superior Protein Therapeutics with Enhanced Efficacy and Broadened Applications
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202403116
Abstract: Protein therapeutics offer high therapeutic potency and specificity; the broader adoptions and development of protein therapeutics, however, have been constricted by their intrinsic limitations such as inadequate stability, immunogenicity, suboptimal pharmacokinetics and biodistribution, and off‐target… read more here.
Keywords: formulation; protein; protein therapeutics; superior protein ... See more keywords
mRNA Sonotransfection of Tumors with Polymeric Microbubbles: Co‐Formulation versus Co‐Administration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202306139
Abstract: Despite its high potential, non‐viral gene therapy of cancer remains challenging due to inefficient nucleic acid delivery. Ultrasound (US) with microbubbles (MB) can open biological barriers and thus improve DNA and mRNA passage. Polymeric MB… read more here.
Keywords: formulation; transfection; mrna sonotransfection; administration ... See more keywords
Optimizing Water‐Blown Lignin‐Based Rigid Polyurethane Foam: Formulation Strategies for Enhanced Mechanical and Thermal Performance
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Applied Polymer Science"
DOI: 10.1002/app.57148
Abstract: Rigid polyurethane foam (RPUF) holds a prominent position in thermal insulation materials. The mechanical and thermal properties of these materials are closely associated with their cell size, structure, and shape. Therefore, optimizing the formulation and… read more here.
Keywords: formulation; lignin based; water blown; rigid polyurethane ... See more keywords
Optimization of liposomal topotecan for use in treating neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1083
Abstract: The purpose of this work was to develop an optimized liposomal formulation of topotecan for use in the treatment of patients with neuroblastoma. Drug exposure time studies were used to determine that topotecan (Hycamtin) exhibited… read more here.
Keywords: topotecan use; formulation; drug; liposomal topotecan ... See more keywords
Engineering Glucagon via Molecular and Formulation Strategies: From Natural Hormone to Effective and Stable Therapeutics
Sign Up to like & getrecommendations! Published in 2025 at "ChemBioChem"
DOI: 10.1002/cbic.202500270
Abstract: Glucagon, a 29‐amino acid pancreatic hormone, plays a central role in glucose homeostasis through activation of the glucagon receptor (GCGR). While clinically essential for hypoglycemia rescue, its broader therapeutic applications face limitations due to challenging… read more here.
Keywords: formulation; formulation strategies; engineering glucagon; glucagon via ... See more keywords
Effect of Colonic Absorption on the Pharmacokinetic Properties of Delayed‐Release and Extended‐Release Methylphenidate: In Vivo, In Vitro, and Modeling Evaluations
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1089
Abstract: Most stimulants used to treat attention‐deficit/hyperactivity disorder are administered in the morning and absorbed in the upper gastrointestinal tract. DR/ER‐MPH (formerly HLD200), an evening‐dosed delayed‐release and extended‐release methylphenidate, is predicted to be absorbed in the… read more here.
Keywords: formulation; release; release methylphenidate; extended release ... See more keywords
Clinical Formulation Bridging of Gefapixant, a P2X3‐Receptor Antagonist, for the Treatment of Chronic Cough
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1105
Abstract: Gefapixant is a P2X3‐receptor antagonist being developed for treatment of refractory or unexplained chronic cough. Four phase 1 studies were conducted in healthy participants that bridged the early‐phase gefapixant formulation (F01) to the phase 3… read more here.
Keywords: receptor antagonist; formulation; chronic cough; p2x3 receptor ... See more keywords
Effects of Tablet Formulation, Food, or Gastric pH on the Bioavailability of Asundexian
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1207
Abstract: Absolute bioavailability (F) and the impact of gastric pH, tablet formulation, and food on the pharmacokinetics and safety of asundexian, an oral factor XIa inhibitor, was assessed in healthy White men aged 18–45 years in… read more here.
Keywords: tablet formulation; formulation; food; bioavailability ... See more keywords
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1208
Abstract: This open‐label, randomized, 3‐treatment, 3‐period, 6‐sequence, crossover study in healthy subjects compared the pharmacokinetic and pharmacodynamic properties of a lipid‐based (soft gelatin capsule) prototype final market image (pFMI) formulation of tropifexor (90‐µg) to its clinical… read more here.
Keywords: formulation; csf; food; concentration ... See more keywords
Pharmacokinetics and Bioequivalence of a Generic Ticagrelor 90‐mg Formulation Versus the Innovator Product in Healthy White Subjects Under Fasting Conditions
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1471
Abstract: Ticagrelor is a key antiplatelet agent used to prevent thrombotic events in patients with acute coronary syndrome. This open‐label, 2‐period, crossover Phase I study assessed the pharmacokinetics and bioequivalence of a generic ticagrelor 90‐mg formulation… read more here.
Keywords: formulation; generic ticagrelor; innovator product; ticagrelor formulation ... See more keywords