Container surfaces control initiation of cavitation and resulting particle formation in protein formulations following application of mechanical shock.
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DOI: 10.1016/j.xphs.2019.11.015
Abstract: Mechanical shock may cause cavitation in vials containing liquid formulations of therapeutic proteins and generate protein aggregates and other particulates. To test whether common formulation components such as protein molecules, air bubbles or polysorbate 20… read more here.
Keywords: following application; formulations following; cavitation; mechanical shock ... See more keywords