Selective Display of a Chemoattractant Agonist on Cancer Cells Activates the Formyl Peptide Receptor 1 on Immune Cells **
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202100521
Abstract: Current immunotherapeutics often work by directing components of the immune system to recognize biomarkers on the surface of cancer cells to generate an immune response. However, variable changes in biomarker distribution and expression can result… read more here.
Keywords: cancer cells; activates formyl; peptide receptor; formyl peptide ... See more keywords
Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses
Sign Up to like & getrecommendations! Published in 2017 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2017.05.001
Abstract: Abstract Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on… read more here.
Keywords: influenza viruses; antiviral activity; activity formyl; pbp10 boc2 ... See more keywords
Biased allosteric modulation of formyl peptide receptor 2 leads to distinct receptor conformational states for pro- and anti-inflammatory signaling.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105117
Abstract: BACKGROUND AND PURPOSE Formyl peptide receptor 2 (FPR2) is a Class A G protein-coupled receptor (GPCR) that interacts with multiple ligands and transduces both proinflammatory and anti-inflammatory signals. These ligands include weak agonists and modulators… read more here.
Keywords: anti inflammatory; conformational states; receptor; peptide receptor ... See more keywords
Formyl peptide receptor 2 and heart disease.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in immunology"
DOI: 10.1016/j.smim.2022.101602
Abstract: Formyl peptide receptor type 2 (FPR2) regulates the initiation and resolution phases of the inflammatory response. In the setting of heart injury and disease, dysregulated inflammation can potentiate maladaptive healing and pathological remodeling of the… read more here.
Keywords: formyl peptide; peptide receptor; heart; heart disease ... See more keywords
68Ga-WRWWWW Is a Potential Positron Emission Tomography Probe for Imaging Inflammatory Diseases by Targeting Formyl Peptide Receptor 2.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00922
Abstract: Inflammation plays a significant role in many physiological and pathological processes. Molecular imaging could provide functional as well as anatomical information for visualizing various inflammatory diseases. Advancements in imaging tracers for inflammation would improve the… read more here.
Keywords: positron emission; formyl peptide; emission tomography; 68ga wrw4 ... See more keywords
Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00079
Abstract: Formyl peptide receptor 2 (FPR2) agonists have shown efficacy in inflammatory-driven animal disease models and have the potential to treat a range of diseases. Many reported synthetic agonists contain a phenylurea, which appears to be… read more here.
Keywords: urea isosteres; heteroaryl urea; discovery heteroaryl; peptide receptor ... See more keywords
Formyl peptide receptor 2 determines sex-specific differences in the progression of nonalcoholic fatty liver disease and steatohepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28138-6
Abstract: Nonalcoholic fatty liver disease (NAFLD) is an important health concern worldwide and progresses into nonalcoholic steatohepatitis (NASH). Although prevalence and severity of NAFLD/NASH are higher in men than premenopausal women, it remains unclear how sex… read more here.
Keywords: formyl peptide; liver disease; fatty liver; sex ... See more keywords
Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1293213
Abstract: ABSTRACT Chronic inflammation can result from inadequate engagement of resolution mechanisms, mainly accomplished by specialized pro-resolving mediators (SPMs) arising from the metabolic activity of lipoxygenases (ALOX5/15) on ω-6 or ω-3 essential polyunsaturated fatty acids (PUFA).… read more here.
Keywords: resolution; inflammation; growth; peptide receptor ... See more keywords
Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16073
Abstract: BACKGROUND AND PURPOSE Acute respiratory distress syndrome (ARDS) is a catastrophic pulmonary inflammatory dysfunction with a high mortality rate. Overwhelming neutrophilic immunity is a key feature in infective or sterile ARDS. Formyl peptide receptor 1… read more here.
Keywords: formyl peptide; respiratory distress; peptide receptor; distress syndrome ... See more keywords
Activation of formyl peptide receptor 1 elicits therapeutic effects against collagen‐induced arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16854
Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder which shows production of autoantibodies, inflammation, bone erosion, swelling and pain in joints. In this study, we examined the effects of an immune‐modulating peptide, WKYMVm, that is an… read more here.
Keywords: induced arthritis; wkymvm; th1 th17; collagen induced ... See more keywords
Formyl peptide receptor 1 signaling potentiates inflammatory brain injury
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abe9890
Abstract: Formyl peptide receptor 1 facilitates brain inflammation and can be targeted to attenuate acute neural injury. Curbing inflammation in ICH Intracerebral hemorrhage (ICH) is associated with increased brain inflammation that contributes to exacerbate cell death… read more here.
Keywords: inflammation; brain; peptide receptor; brain inflammation ... See more keywords