Characterization of CFTR Activators and Inhibitors by the use of a Planar Patch Clamp System
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2561
Abstract: Cystic fibrosis is caused by malfunction of the chloride channel Cystic Fibrosis Transmembrane Regulator (CFTR). CFTR is expressed in the apical membrane of epithelial cells where it is involved in the regulation of fluid transport… read more here.
Keywords: activators inhibitors; cftr; characterization cftr; forskolin ... See more keywords
Forskolin and protein kinase inhibitors differentially affect hair cell potassium currents and transmitter release at the cytoneural junction in the isolated frog labyrinth
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.05.039
Abstract: The post-transductional elaboration of sensory input at the frog semicircular canal has been studied by correlating the effects of drugs that interfere with phosphorylation processes on: (i) potassium conductances in isolated hair cell and (ii)… read more here.
Keywords: transmitter release; hair cell; kinase; hair ... See more keywords
Adenosine and Forskolin Inhibit Platelet Aggregation by Collagen but not the Proximal Signalling Events.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1688788
Abstract: BACKGROUND The G protein-coupled receptor, adenosine A2A, signals through the stimulatory G protein, Gs, in platelets leading to activation of adenylyl cyclase and elevation of cyclic adenosine monophosphate (cAMP) and inhibition of platelet activation. OBJECTIVE… read more here.
Keywords: collagen; forskolin; activation; receptor ... See more keywords
The adenylate cyclase activator forskolin potentiates the positive inotropic effect of the phosphodiesterase inhibitor milrinone but not of the calcium sensitizer levosimendan nor of its hemodynamically active metabolites: an apparent conundrum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiovascular pharmacology"
DOI: 10.1097/fjc.0000000000001235
Abstract: ABSTRACT OR-1855 and OR-1896 are two hemodynamically active metabolites of the inodilator levosimendan, with calcium sensitizing activity, but their mechanism of action is still not fully understood.It has been previously reported that the positive inotropic… read more here.
Keywords: inotropic effect; positive inotropic; forskolin; active metabolites ... See more keywords
Engineering of CYP76AH15 can improve activity and specificity towards forskolin biosynthesis in yeast
Sign Up to like & getrecommendations! Published in 2018 at "Microbial Cell Factories"
DOI: 10.1186/s12934-018-1027-3
Abstract: BackgroundForskolin is a high-value diterpenoid produced exclusively by the Lamiaceae plant Coleus forskohlii. Today forskolin is used pharmaceutically for its adenyl-cyclase activating properties. The limited availability of pure forskolin is currently hindering its full utilization,… read more here.
Keywords: production; forskolin; manoyl oxide; cyp76ah15 ... See more keywords
Forskolin Induces Endocrine Disturbance in Human JEG-3 Placental Cells
Sign Up to like & getrecommendations! Published in 2022 at "Toxics"
DOI: 10.3390/toxics10070355
Abstract: Forskolin, used in folk medicine since ancient times, is now available as a dietary supplement, with an indication as a fat burner and appetite suppressant. However, the safety of forskolin is poorly documented especially for… read more here.
Keywords: forskolin; jeg; pregnant women; placental cells ... See more keywords
Total biosynthesis of the cyclic AMP booster forskolin from Coleus forskohlii
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.23001
Abstract: Forskolin is a unique structurally complex labdane-type diterpenoid used in the treatment of glaucoma and heart failure based on its activity as a cyclic AMP booster. Commercial production of forskolin relies exclusively on extraction from… read more here.
Keywords: amp booster; cyclic amp; forskolin; coleus forskohlii ... See more keywords