‘Forward genetics’ and the causes of ALS
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0062-6
Abstract: Adriano Aguzzi discusses the endeavours of the Gitler team to identify the causes underlying the fatal human neurological disease amyotrophic lateral sclerosis (ALS). read more here.
Keywords: forward genetics; causes als; genetics; genetics causes ... See more keywords
Flash forward genetics: new twists in transcription across evolutionary boundaries
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DOI: 10.15252/embr.202052152
Abstract: “Flash forward genetics” refers to a genetic approach based on the functional interaction of a given factor with unknown partner(s) converging on shared targets across evolutionary boundaries. A study by Li et al (2021), published… read more here.
Keywords: transcription; forward genetics; flash forward; across evolutionary ... See more keywords
Forward Genetics in Apicomplexa Biology: The Host Side of the Story
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.878475
Abstract: Forward genetic approaches have been widely used in parasitology and have proven their power to reveal the complexities of host-parasite interactions in an unbiased fashion. Many aspects of the parasite’s biology, including the identification of… read more here.
Keywords: forward genetics; genetic approaches; forward genetic; host ... See more keywords
Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy
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DOI: 10.3390/ijms24065280
Abstract: Epilepsy is a highly prevalent, severely debilitating neurological disorder characterized by seizures and neuronal hyperactivity due to an imbalanced neurotransmission. As genetic factors play a key role in epilepsy and its treatment, various genetic and… read more here.
Keywords: downstream pathways; forward genetics; molecular mechanisms; epilepsy ... See more keywords