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   Articles with "forward loop" as a keyword



Homeostasis in a feed forward loop gene regulatory motif.

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recommendations! Published in 2018 at "Journal of theoretical biology"

DOI: 10.1016/j.jtbi.2018.02.026

Abstract: The internal state of a cell is affected by inputs from the extra-cellular environment such as external temperature. If some output, such as the concentration of a target protein, remains approximately constant as inputs vary,… read more here.

Keywords: homeostasis; gene regulatory; forward loop; feed forward ... See more keywords

A coherent FOXO3-SNAI2 feed-forward loop in autophagy

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2118285119

Abstract: Significance Understanding autophagy regulation is instrumental in developing therapeutic interventions for autophagy-associated disease. Here, we identified SNAI2 as a regulator of autophagy from a genome-wide screen in HeLa cells. Upon energy stress, SNAI2 is transcriptionally… read more here.

Keywords: snai2; feed forward; coherent foxo3; forward loop ... See more keywords

Platelets engage mast cells in a bilateral IL-33-driven feed-forward loop.

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2512193122

Abstract: Platelets amplify type 2 inflammation (T2I) through incompletely understood mechanisms. Depletion of platelets markedly attenuated mast cell (MC) activation in a model of aspirin exacerbated respiratory disease (AERD) that depends on IL-33 and cysteinyl leukotrienes… read more here.

Keywords: platelets engage; driven feed; forward loop; engage mast ... See more keywords

Coherent feed-forward loop acts as an efficient information transmitting motif.

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recommendations! Published in 2020 at "Physical review. E"

DOI: 10.1103/physreve.101.022407

Abstract: We present a theoretical formalism to study steady-state information transmission in a coherent type-1 feed-forward loop motif with an additive signal integration mechanism. Our construct allows a two-step cascade to be slowly transformed into a… read more here.

Keywords: forward loop; motif; feed forward; network ... See more keywords