20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.11.008
Abstract: 20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects… read more here.
Keywords: fos jun; protopanaxadiol ppd; ppd; expression egr ... See more keywords
AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.11.026
Abstract: Enhancer elements are genomic regulatory sequences that direct the selective expression of genes so that genetically identical cells can differentiate and acquire the highly specialized forms and functions required to build a functioning animal. To… read more here.
Keywords: fos jun; enhancer selection; transcription factors; enhancer ... See more keywords
Synsepalum dulcificum extracts exhibit cytotoxic activity on human colorectal cancer cells and upregulate c-fos and c-jun early apoptotic gene expression
Sign Up to like & getrecommendations! Published in 2018 at "Asian Pacific Journal of Tropical Biomedicine"
DOI: 10.4103/2221-1691.227999
Abstract: Objective: To explore cytotoxicity of Synsepalum dulcificum (S. dulcificum) Daniell (Sapotaceae) on human colon cancer (HCT-116 and HT-29), human monocytic leukemia (THP-1) and normal (HDFn) cell lines, and its effect on the expression of early… read more here.
Keywords: fos jun; hct 116; early apoptotic; expression ... See more keywords