Chitooligosaccharide inhibits RANKL‐induced osteoclastogenesis and ligation‐induced periodontitis by suppressing MAPK/ c‐fos/NFATC1 signaling
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DOI: 10.1002/jcp.29207
Abstract: Considering the high rate of osteoclast‐related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose‐dependently. CS suppressed osteoclast‐specific genes expression… read more here.
Keywords: induced osteoclastogenesis; mapk fos; fos nfatc1; rankl induced ... See more keywords
Histone deacetylase inhibitor CI‐994 inhibits osteoclastogenesis via suppressing NF‐&kgr;B and the downstream c‐Fos/NFATc1 signaling pathways
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DOI: 10.1016/j.ejphar.2019.01.021
Abstract: &NA; [4‐(acetylamino)‐N‐(2‐amino‐phenyl) benzamide] (CI‐994) is a histone deacetylase 1‐3 specific inhibitor that has been shown to indirectly increase the production of Dickkopf‐1, which is an inhibitor of osteoclastic development. However, whether CI‐994 has an influence… read more here.
Keywords: inhibitor; fos nfatc1; fos; downstream fos ... See more keywords
Trimethylamine-N-Oxide Promotes Osteoclast Differentiation and Bone Loss via Activating ROS-Dependent NF-κB Signaling Pathway
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DOI: 10.3390/nu14193955
Abstract: Trimethylamine-N-oxide (TMAO), an important gut microbiota (GM)-derived metabolite, has been shown to be abnormally increased in osteoporosis. However, the role and underlying mechanism of TMAO in regulating bone loss during osteoporosis have not been fully… read more here.
Keywords: signaling pathway; bone; fos nfatc1; expression ... See more keywords