Prevalence and Mechanisms of Fosfomycin Resistance among KPC-Producing Klebsiella pneumoniae Clinical Isolates in China.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106226
Abstract: The threat of antibiotic resistance has been increased dramatically during last few years, an old antibiotic agent, fosfomycin, has been re-introduced to fight against infections caused by Klebsiella pneumoniae carbapenemase -producing K. pneumonia (KPC-KP). However,… read more here.
Keywords: among kpc; resistance among; klebsiella pneumoniae; resistance ... See more keywords
Mechanisms of high-level fosfomycin resistance in Staphylococcus aureus epidemic lineage ST5
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DOI: 10.1093/jac/dkac236
Abstract: Abstract Objectives Fosfomycin resistance has become a clinical concern. In this study, we analysed the dynamic change of fosfomycin MIC in the epidemic Staphylococcus aureus lineages in a teaching hospital in Shanghai for 12 years and… read more here.
Keywords: high level; fosfomycin resistance; resistance; level fosfomycin ... See more keywords
Differences in Fosfomycin Resistance Mechanisms between Pseudomonas aeruginosa and Enterobacterales
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DOI: 10.1128/aac.01446-21
Abstract: Multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to public health due to its widespread resistance to numerous antibiotics. P. aeruginosa commonly causes nosocomial infections including urinary tract infections (UTI) which have become increasingly difficult… read more here.
Keywords: drug; resistance; resistance mechanisms; pseudomonas aeruginosa ... See more keywords
Aliidiomarina shirensis as Possible Source of the Integron- and Plasmid-Mediated Fosfomycin Resistance Gene fosC2
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DOI: 10.1128/aac.02227-21
Abstract: In-silico analysis and cloning experiments identified a fosC2-like fosfomycin resistance gene in the chromosome of Aliidiomarina shirensis, with our data suggesting that this bacterium might be added to the list of species identified as reservoirs… read more here.
Keywords: fosfomycin resistance; resistance gene; aliidiomarina shirensis; gene ... See more keywords
Widespread Fosfomycin Resistance in Gram-Negative Bacteria Attributable to the Chromosomal fosA Gene
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DOI: 10.1128/mbio.00749-17
Abstract: ABSTRACT Fosfomycin is a decades-old antibiotic which is being revisited because of its perceived activity against many extensively drug-resistant Gram-negative pathogens. FosA proteins are Mn2+ and K+-dependent glutathione S-transferases which confer fosfomycin resistance in Gram-negative… read more here.
Keywords: gram negative; fosfomycin resistance; fosa; negative bacteria ... See more keywords
Polyclonal Spread of Fosfomycin Resistance among Carbapenemase-Producing Members of the Enterobacterales in the Czech Republic
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DOI: 10.1128/spectrum.00095-23
Abstract: Antimicrobial resistance (AMR) currently represents a concern for human health, and the reintroduction of antibiotics such as fosfomycin into clinical practice can provide further option in treatment of multidrug-resistant (MDR) bacterial infections. However, there is… read more here.
Keywords: czech republic; fosfomycin resistance; spread fosfomycin; resistance ... See more keywords
Prevalence of fosfomycin resistance and gene mutations in clinical isolates of methicillin-resistant Staphylococcus aureus
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DOI: 10.1186/s13756-020-00790-x
Abstract: Fosfomycin exhibits excellent in vitro activity against multidrug-resistant pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Increasing fosfomycin resistance among clinical MRSA isolates was reported previously, but little is known about the relative abundance of Fosfomycin resistance… read more here.
Keywords: gene; fosfomycin resistance; resistance; mrsa isolates ... See more keywords
Characterization of Extended-Spectrum β-Lactamase Genes of Shigella flexneri Isolates With Fosfomycin Resistance From Patients in China
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DOI: 10.3343/alm.2017.37.5.415
Abstract: Background The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study was to identify fosfomycin resistance… read more here.
Keywords: flexneri isolates; lactamase genes; resistance; fosfomycin resistance ... See more keywords
Transporter Genes and fosA Associated With Fosfomycin Resistance in Carbapenem-Resistant Klebsiella pneumoniae
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DOI: 10.3389/fmicb.2022.816806
Abstract: Infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP) are of significant clinical concern worldwide. Fosfomycin is one of the limited treatment options for CRKP. However, resistance to fosfomycin in CRKP has been observed. In this study,… read more here.
Keywords: fosfomycin resistance; klebsiella pneumoniae; resistance; resistant klebsiella ... See more keywords
Fosfomycin Resistance Evolutionary Pathways of Stenotrophomonas maltophilia in Different Growing Conditions
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DOI: 10.3390/ijms23031132
Abstract: The rise of multidrug-resistant Gram-negative pathogens and the lack of novel antibiotics to address this problem has led to the rescue of old antibiotics without a relevant use, such as fosfomycin. Stenotrophomonas maltophilia is a… read more here.
Keywords: fosfomycin resistance; growing conditions; stenotrophomonas maltophilia; evolutionary pathways ... See more keywords