The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.
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DOI: 10.1016/j.celrep.2020.107826
Abstract: Regulatory T cells (Tregs) represent a major population in the control of immune homeostasis and autoimmunity. Here we show that Fos-like 2 (Fosl2), a TCR-induced AP1 transcription factor, represses Treg development and controls autoimmunity. Mice overexpressing… read more here.
Keywords: treg development; fosl2; ap1 transcription; autoimmunity ... See more keywords
HGF/MET Regulated Epithelial-Mesenchymal Transitions And Metastasis By FOSL2 In Non-Small Cell Lung Cancer
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DOI: 10.2147/ott.s217595
Abstract: Background HGF/MET has been found to be associated with non-small cell lung cancer (NSCLC). However, the underlying molecular mechanisms of HGF/MET involved in regulating the metastasis of NSCLC remain unclear. Methods The effect of HGF/MET… read more here.
Keywords: small cell; hgf met; metastasis; non small ... See more keywords
MicroRNA (miR)-597-5p Inhibits Colon Cancer Cell Migration and Invasion by Targeting FOS-Like Antigen 2 (FOSL2)
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DOI: 10.3389/fonc.2019.00495
Abstract: Our previous work had shown that FOS-like antigen 2 (FOSL2) is regulated by miR-143-5p in colorectal cancer (CRC). Given that it has been shown by others that FOSL2 is also a target of miR-597-5p in… read more here.
Keywords: mir 597; fosl2; expression; cancer ... See more keywords