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   Articles with "fosl2" as a keyword



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The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.107826

Abstract: Regulatory T cells (Tregs) represent a major population in the control of immune homeostasis and autoimmunity. Here we show that Fos-like 2 (Fosl2), a TCR-induced AP1 transcription factor, represses Treg development and controls autoimmunity. Mice overexpressing… read more here.

Keywords: treg development; fosl2; ap1 transcription; autoimmunity ... See more keywords

Fosl2 facilitates chromatin accessibility to determine developmental events during follicular maturation

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-64009-6

Abstract: Granulosa cells (GCs) are the most dynamically responsive cell lineage to encourage continuous folliculogenesis; however, developmental dynamics and interplay with downstream transcription circuitry remain unclear. Here, we unravel the redistribution of genome-wide chromatin areas that… read more here.

Keywords: chromatin accessibility; fosl2; follicular maturation; accessibility ... See more keywords

HGF/MET Regulated Epithelial-Mesenchymal Transitions And Metastasis By FOSL2 In Non-Small Cell Lung Cancer

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recommendations! Published in 2019 at "OncoTargets and therapy"

DOI: 10.2147/ott.s217595

Abstract: Background HGF/MET has been found to be associated with non-small cell lung cancer (NSCLC). However, the underlying molecular mechanisms of HGF/MET involved in regulating the metastasis of NSCLC remain unclear. Methods The effect of HGF/MET… read more here.

Keywords: small cell; hgf met; metastasis; non small ... See more keywords

MicroRNA (miR)-597-5p Inhibits Colon Cancer Cell Migration and Invasion by Targeting FOS-Like Antigen 2 (FOSL2)

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recommendations! Published in 2019 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2019.00495

Abstract: Our previous work had shown that FOS-like antigen 2 (FOSL2) is regulated by miR-143-5p in colorectal cancer (CRC). Given that it has been shown by others that FOSL2 is also a target of miR-597-5p in… read more here.

Keywords: mir 597; fosl2; expression; cancer ... See more keywords

Fosl2 Deficiency Predisposes Mice to Osteopetrosis, Leading to Bone Marrow Failure.

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recommendations! Published in 2024 at "Journal of immunology"

DOI: 10.4049/jimmunol.2300592

Abstract: Arthritis causes Fos-like 2 (Fosl2) inactivation, and various immune cells contribute to its pathogenesis. However, little is known about the role of Fosl2 in hematopoiesis and the possible pathological role of Fosl2 inactivation in the… read more here.

Keywords: osteopetrosis; bone marrow; cell; fosl2 ... See more keywords