Stimulation of the four isoforms of receptor tyrosine kinase ErbB4, but not ErbB1, confers cardiomyocyte hypertrophy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30487
Abstract: Epidermal growth factor (EGF) receptors (ErbB1-ErbB4) promote cardiac development and growth, although the specific EGF ligands and receptor isoforms involved in growth/repair versus pathology remain undefined. We challenged ventricular cardiomyocytes with EGF-like ligands and observed… read more here.
Keywords: four isoforms; erbb4; hypertrophy; erbb1 ... See more keywords