A comparative study on pathological features of transgenic rat lines expressing either three or four repeat misfolded tau
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24447
Abstract: Human tauopathies represent a heterogeneous group of neurodegenerative disorders characterized by distinct clinical features, typical histopathological structures, and defined ratio(s) of three‐repeat and four‐repeat tau isoforms within pathological aggregates. How the optional microtubule‐binding repeat of… read more here.
Keywords: repeat; three four; pathology; repeat tau ... See more keywords
Four‐repeat tauopathies and late‐onset psychiatric disorders: Etiological relevance or incidental findings?
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DOI: 10.1111/neup.12820
Abstract: Argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP) and corticobasal degeneration are four‐repeat (4R) tauopathies that develop in the presenium or later. Whether these diseases are associated with the occurrence of late‐onset psychiatric disorders remains… read more here.
Keywords: psychiatric disorders; four repeat; onset psychiatric; case ... See more keywords
Unclassified four-repeat tauopathy associated with familial parkinsonism and progressive respiratory failure
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01025-1
Abstract: We describe an autopsied patient with familial parkinsonism and unclassified four repeat-tau (4R-tau) aggregation. She presented with bradykinesia, truncal dystonia, and mild amnesia at the age of 61 and then exhibited body weight loss (15 kg… read more here.
Keywords: unclassified four; familial parkinsonism; parkinsonism; respiratory failure ... See more keywords