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   Articles with "foxa1" as a keyword



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SOX9 dependent FOXA1 expression promotes tumorigenesis in lung carcinoma.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.05.169

Abstract: The malignant proliferation is one of the major characteristic for tumor cells, however the mechanism of lung cancer cells uncontrollable proliferation is still confusing. This study investigated the mechanism of up-regulated FOXA1 in lung cancer… read more here.

Keywords: foxa1; expression; sox9; lung cancer ... See more keywords
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Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling

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recommendations! Published in 2019 at "Cell Reports"

DOI: 10.1016/j.celrep.2019.02.036

Abstract: Summary Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which… read more here.

Keywords: analysis reveals; comprehensive genomic; foxa1 binding; foxa1 ... See more keywords
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Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14709

Abstract: Neurons reprogramme encephalitogenic T cells (Tenc) to regulatory T cells (Tregs), either FoxP3+Tregs or FoxA1+Tregs. We reported previously that neuronal ability to generate FoxA1+Tregs was central to preventing neuroinflammation in experimental autoimmune encephalomyelitis (EAE). Mice… read more here.

Keywords: foxa1; foxa1 tregs; neuronal ifn; pi3k akt ... See more keywords
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Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer

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recommendations! Published in 2021 at "Science Advances"

DOI: 10.1126/sciadv.abe2261

Abstract: FOXA1 is a nonhistone substrate of EZH2, promoting cell growth and sensitizing some prostate cancer to enzymatic EZH2 inhibitors. Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer (PCa) growth. However, how FOXA1… read more here.

Keywords: growth; foxa1; prostate cancer; ezh2 ... See more keywords
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Abstract 4998: Breast tumor FOXA1 protein expression and reproductive characteristics among African-American and European-American women

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-4998

Abstract: Background: Forkhead box protein A1 (FOXA1) plays a key role in determining estrogen receptor (ER) function and mammary ductal development and may repress the basal cell phenotype during differentiation of breast epithelium. While reproductive factors… read more here.

Keywords: protein; breast; breast cancer; foxa1 ... See more keywords
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Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.prca2023-a056

Abstract: The identity of the prostate gland is defined by transcription factors (TF) like the androgen receptor (AR), FOXA1, and NKX3.1 that bind regulatory elements early in development to activate the lineage gene program. For instance,… read more here.

Keywords: foxa1; gene repression; prostate carcinogenesis; deptor ... See more keywords

Abstract PD7-01: Identification of a high FOXA1-induced pro-metastatic enhancer signature in endocrine-resistant and metastatic breast cancer

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recommendations! Published in 2020 at "Cancer Research"

DOI: 10.1158/1538-7445.sabcs19-pd7-01

Abstract: Background: Forkhead box A1 (FOXA1) is a pioneer transcription factor (TF) for chromatin binding and function of other lineage-specific TFs essential for the normal development of endoderm-derived organs. Aberrant FOXA1 signaling, due to genetic amplification… read more here.

Keywords: enhancer signature; foxa1; foxa1 induced; pro metastatic ... See more keywords

miR-204 regulates the biological behavior of breast cancer MCF-7 cells by directly targeting FOXA1.

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recommendations! Published in 2017 at "Oncology reports"

DOI: 10.3892/or.2017.5644

Abstract: MicroRNAs (miRNAs) are short, non-protein-coding RNAs and transcripts that are 18-24 nt in length. miR-204 was first identified as an anti-oncogene and is reported to be downregulated in non-small cell lung cancer, glioma, gastric and thyroid… read more here.

Keywords: mcf cells; breast cancer; foxa1; cancer ... See more keywords

FOXA1 and CK7 expression in esophageal squamous cell carcinoma and its prognostic significance.

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recommendations! Published in 2018 at "Neoplasma"

DOI: 10.4149/neo_2018_170529n384

Abstract: Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant tumors in human. Some ESCC cells express adenocarcinoma cell markers, such as Cytokeratin 7 (CK7), but the clinical significance of these cells in… read more here.

Keywords: ck7; foxa1; escc; expression ... See more keywords