SOX9 dependent FOXA1 expression promotes tumorigenesis in lung carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.169
Abstract: The malignant proliferation is one of the major characteristic for tumor cells, however the mechanism of lung cancer cells uncontrollable proliferation is still confusing. This study investigated the mechanism of up-regulated FOXA1 in lung cancer… read more here.
Keywords: foxa1; expression; sox9; lung cancer ... See more keywords
Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.02.036
Abstract: Summary Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which… read more here.
Keywords: analysis reveals; comprehensive genomic; foxa1 binding; foxa1 ... See more keywords
Neuronal IFN-beta–induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14709
Abstract: Neurons reprogramme encephalitogenic T cells (Tenc) to regulatory T cells (Tregs), either FoxP3+Tregs or FoxA1+Tregs. We reported previously that neuronal ability to generate FoxA1+Tregs was central to preventing neuroinflammation in experimental autoimmune encephalomyelitis (EAE). Mice… read more here.
Keywords: foxa1; foxa1 tregs; neuronal ifn; pi3k akt ... See more keywords
Targeting the FOXA1/BMI1 axis to overcome chemoresistance and suppress tumor progression in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02595-6
Abstract: Nasopharyngeal carcinoma (NPC) is a highly aggressive head and neck cancer characterized by a complex etiology and a propensity for metastasis. The current study explores the intricate relationship between Forkhead Box A1 (FOXA1) and B-cell-specific… read more here.
Keywords: foxa1 bmi1; foxa1; progression; nasopharyngeal carcinoma ... See more keywords
NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Genetics"
DOI: 10.1038/s41588-024-01893-6
Abstract: Androgen receptor (AR) is a ligand-responsive transcription factor that drives terminal differentiation of the prostatic luminal epithelia. By contrast, in tumors originating from these cells, AR chromatin occupancy is extensively reprogrammed to activate malignant phenotypes,… read more here.
Keywords: cancer; subunit; foxa1; prostate cancer ... See more keywords
Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2024 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2024.2307574
Abstract: Abstract Transcription factors play key roles in development and disease by controlling gene expression. Forkhead box A1 (FOXA1), is a pioneer transcription factor essential for mouse development and functions as an oncogene in prostate and… read more here.
Keywords: foxa1 mrna; foxa1; colorectal cancer; crc cells ... See more keywords
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abe2261
Abstract: FOXA1 is a nonhistone substrate of EZH2, promoting cell growth and sensitizing some prostate cancer to enzymatic EZH2 inhibitors. Forkhead box protein A1 (FOXA1) is essential for androgen-dependent prostate cancer (PCa) growth. However, how FOXA1… read more here.
Keywords: growth; foxa1; prostate cancer; ezh2 ... See more keywords
FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-010091
Abstract: Background Nasopharyngeal carcinoma (NPC) is a distinct subtype of head and neck cancer which is prevalent in south of China and southeastern of Asia. Consistent activation of interferon (IFN) signaling, and impairment of T cell… read more here.
Keywords: npc cells; foxa1; interferon; nasopharyngeal carcinoma ... See more keywords
Abstract 4998: Breast tumor FOXA1 protein expression and reproductive characteristics among African-American and European-American women
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4998
Abstract: Background: Forkhead box protein A1 (FOXA1) plays a key role in determining estrogen receptor (ER) function and mammary ductal development and may repress the basal cell phenotype during differentiation of breast epithelium. While reproductive factors… read more here.
Keywords: protein; breast; breast cancer; foxa1 ... See more keywords
Abstract LB312: FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-lb312
Abstract: Gain of function mutations in the pioneer transcription factor FOXA1 are found in 10-40% of human prostate cancers. These mutations rewire global chromatin accessibility, driving prostate cell growth, yet the underlying molecular details behind this… read more here.
Keywords: transcription factor; foxa1; tumorigenicity; prostate ... See more keywords
Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a056
Abstract: The identity of the prostate gland is defined by transcription factors (TF) like the androgen receptor (AR), FOXA1, and NKX3.1 that bind regulatory elements early in development to activate the lineage gene program. For instance,… read more here.
Keywords: foxa1; gene repression; prostate carcinogenesis; deptor ... See more keywords