The reduction in FOXA2 activity during lung development in fetuses from diabetic rat mothers is reversed by Akt inhibition
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12517
Abstract: Hyperglycemia during pregnancy is associated with fetal lung development disorders and surfactant protein (SP) deficiency. Here, we examined the role of FOXA2 and Akt signaling in fetal lung development during diabetic pregnancy. Sprague‐Dawley rats were… read more here.
Keywords: reduction foxa2; foxa2; fetal lung; lung development ... See more keywords
FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2‐mediated glycolysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29759
Abstract: FoxA2 is an essential transcription factor for liver organogenesis and homeostasis. Although reduced expression of FoxA2 has been associated with chronic liver diseases, hepatic progenitor cells (HPCs) that are activated in these circumstances express FoxA2.… read more here.
Keywords: foxa2; glycolysis; pi3k akt; proliferation ... See more keywords
FOXA2 inhibits doxorubicin-induced apoptosis via transcriptionally activating HBP rate-limiting enzyme GFPT1 in HCC cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-021-00829-6
Abstract: Apoptosis plays an important role in both carcinogenesis and cancer treatment. Understanding the mechanisms through which resistance to apoptosis occurs in cancer cells has huge implications for cancer treatment. Although pieces of evidence have shown… read more here.
Keywords: foxa2; apoptosis; induced apoptosis; hcc cells ... See more keywords
FOXA1 and FOXA2: the regulatory mechanisms and therapeutic implications in cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-01936-1
Abstract: FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, including organogenesis and differentiation, glycolipid metabolism, proliferation, migration… read more here.
Keywords: cancer; foxa2 regulatory; foxa2; regulatory mechanisms ... See more keywords
Upregulation of FOXA2 in uterine luminal epithelium and vaginal basal epithelium of epiERα–/– (Esr1fl/flWnt7aCre/+) mice
Sign Up to like & getrecommendations! Published in 2023 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac225
Abstract: Abstract Forkhead box protein A2 (FOXA2) is a pioneer transcription factor important for epithelial budding and morphogenesis in different organs. It has been used as a specific marker for uterine glandular epithelial cells (GE). FOXA2… read more here.
Keywords: epithelium; epier esr1fl; basal; foxa2 ... See more keywords
Conditional Tissue-Specific Foxa2 Ablation in Mouse Pancreas Causes Hyperinsulinemic Hypoglycemia: (RETRACTED)
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Therapeutics"
DOI: 10.1097/mjt.0000000000000399
Abstract: The forkhead/winged helix transcription factor Foxa2 is a major upstream regulator of Pdx1, a transcription factor necessary for pancreatic development. In the present study, we conditionally knocked out Foxa2 in Pdx1-expressing domain and further analyzed… read more here.
Keywords: bgr; foxa2; foxa2 mice; pdx1cre foxa2 ... See more keywords
Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.15.484401
Abstract: Embryonic diapause is a reproductive strategy in which embryo development and growth is temporarily arrested within the uterus to ensure the survival of neonates and mothers during unfavorable conditions. Pregnancy is reinitiated when conditions become… read more here.
Keywords: embryonic diapause; foxa2; depletion uterine; mice ... See more keywords
Abstract 1488: The FOXA2 contributes to tumor proliferation and invasion via HGF mediated ERK signaling pathway in human gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1488
Abstract: Background: FOXA1 and FOXA2, members of the forkhead transcription factor family, are critical for epithelial differentiation in many endoderm-derived organs and important regulators in body homeostasis. It has been shown that FOXA2 plays an important… read more here.
Keywords: human gastric; proliferation; foxa2; gastric cancer ... See more keywords
Abstract 4753: LSD1 &8211mediated FOXA2/AP1 transcription program drives lineage plasticity in prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4753
Abstract: Background: While castration-resistant PCa (CRPC) can be further treated with second-generation androgen deprivation therapies (ADTs), the tumor can quickly generate resistance through multiple mechanisms. One critical mechanism is that tumor cells can progress to AR-indifferent… read more here.
Keywords: lineage plasticity; transcription; foxa2; crpc ... See more keywords
Abstract 59: The pioneer transcription factor FOXA2 regulates integrin alpha 1 expression controlling prostate cancer bone colonization
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-59
Abstract: Introduction. Approximately 30,000 men will die from prostate cancer (PCa) in 2018. When localized and detected early, it has a low rate of progression and metastasis, with successful treatment. However, some patients may progress to… read more here.
Keywords: expression; pca; foxa2; prostate cancer ... See more keywords
9194 Generation of a Human-Induced Pluripotent Stem Cell Line From a Patient With Hypopituitarism and a Novel Nonsense Variant in FOXA2
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.1220
Abstract: Abstract Disclosure: M.A. Camilletti: None. G.T. Chirino Felker: None. G. Amin: None. S. Castañeda: None. F. Zabalegui: None. C. Romano Florit: None. A. Waisman: None. M. Ciaccio: None. M.I. Di Palma: None. E. Vaiani: None.… read more here.
Keywords: foxa2mut ipsc; none; stem cell; cell ... See more keywords