FOXC1 is associated with estrogen receptor alpha and affects sensitivity of tamoxifen treatment in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.990
Abstract: FOXC1 is a member of Forkhead box transcription factors that participates in embryonic development and tumorigenesis. Our previous study demonstrated that FOXC1 was highly expressed in triple‐negative breast cancer. However, it remains unclear what is… read more here.
Keywords: foxc1; breast cancer; expression; cancer ... See more keywords
FOXC1 Aggravates the Ischemia‐Reperfusion Induced Injury in Renal Tubular Epithelial Cells by Activating NF‐κB/NLRP3 Signaling
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70301
Abstract: Renal ischemia‐reperfusion injury (RIRI) is a condition characterized by inflammation and cell damage in the kidneys following a period of ischemia and subsequent reperfusion, which lacks effective treating method in the clinic. Exploring molecular mechanisms… read more here.
Keywords: induced injury; ischemia reperfusion; foxc1; injury renal ... See more keywords
FOXC1 negatively regulates BMP‐SMAD activity and Id1 expression during osteoblast differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29595
Abstract: Bone morphogenetic proteins regulate a diverse range of biological processes through their activation of SMAD1, SMAD5, or SMAD8 proteins that, in turn, regulate gene expression. These SMAD transcription factors achieve a layer of functional specificity… read more here.
Keywords: foxc1; expression; differentiation; osteoblast differentiation ... See more keywords
EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers.
Sign Up to like & getrecommendations! Published in 2020 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-020-00543-x
Abstract: Triple-negative breast cancer (TNBC) is characterized by low expression of human epidermal growth factor receptor-2 (HER2), estrogen receptor (ER), and progesterone receptor (PR), which is the most aggressive subtype with poor outcome among breast cancers.… read more here.
Keywords: ezh2 regulates; breast; foxc1; breast cancers ... See more keywords
Evaluation of FOXC1 as a therapeutic target for basal-like breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Gene Therapy"
DOI: 10.1038/s41417-018-0010-9
Abstract: Basal-like breast cancer (BLBC) is a malignant carcinoma with aggressive motility and rapid growth. Accounting for 15% of breast cancers, BLBC often exhibits a poor prognosis and tends to metastasize to the brain and lungs.… read more here.
Keywords: breast; blbc; foxc1; cancer ... See more keywords
Phenotype expansion of heterozygous FOXC1 pathogenic variants toward involvement of congenital anomalies of the kidneys and urinary tract (CAKUT)
Sign Up to like & getrecommendations! Published in 2020 at "Genetics in Medicine"
DOI: 10.1038/s41436-020-0844-z
Abstract: Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in childhood and adolescence. We aim to identify novel monogenic causes of CAKUT. Exome sequencing was performed… read more here.
Keywords: congenital anomalies; urinary tract; pathogenic variants; cakut ... See more keywords
MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1933679
Abstract: Emerging evidence has exhibited an obvious decreased expression of miR-106a-5p in the ectopic endometrial tissue of endometriosis (EMS) patients. Thus far, the pathophysiological function of miR-106a-5p in EMS is unknown. A previous study showed an… read more here.
Keywords: pi3k; foxc1; endometrial stromal; ectopic endometrial ... See more keywords
Forkhead-box C1 attenuates high glucose-induced trophoblast cell injury during gestational diabetes mellitus via activating adenosine monophosphate-activated protein kinase through regulating fibroblast growth factor 19
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018094
Abstract: ABSTRACT Gestational diabetes mellitus (GDM) is a complication developed during pregnancy and recover after childbirth. The purpose of this study was to investigate the protective role of FOXC1 during GDM and the underlying mechanism. FOXC1… read more here.
Keywords: cell; trophoblast cell; gestational diabetes; diabetes mellitus ... See more keywords
CSIG-07. THE ROLE OF FOXC1 IN PATIENT-DERIVED AGGRESSIVE MENINGIOMA CELL LINES
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0341
Abstract: Meningiomas are the most commonly occurring intracranial tumors. While most are benign, the World Health Organization (WHO) classifies Grade II and Grade III meningiomas as atypical and anaplastic, indicating a more aggressive behavior. However, only… read more here.
Keywords: cell lines; patient derived; foxc1; aggressive meningioma ... See more keywords
FOXC1 and FOXC2 Ablation Causes Abnormal Valvular Endothelial Cell Junctions and Lymphatic Vessel Formation in Myxomatous Mitral Valve Degeneration
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.124.320316
Abstract: BACKGROUND: Mitral valve (MV) disease including myxomatous degeneration is the most common form of valvular heart disease with an age-dependent frequency. Genetic evidence indicates that mutations of the human transcription factor FOXC1 are associated with… read more here.
Keywords: mice; foxc1; degeneration; mvs ... See more keywords
FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles
Sign Up to like & getrecommendations! Published in 2017 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758834017742576
Abstract: Forkhead box C1 (FOXC1) is an essential member of the forkhead box transcription factors and has been highlighted as an important transcriptional regulator of crucial proteins associated with a wide variety of carcinomas. FOXC1 regulates… read more here.
Keywords: cancer development; foxc1; expression; cancer ... See more keywords