O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61022-7
Abstract: The E2F transcription factors constitute a core transcriptional network that governs cell division and oncogenesis in multi-cellular organisms, although their molecular mechanisms remain incompletely understood. Here, we show that elevated expression of the transcription factor… read more here.
Keywords: e2f pathway; foxk1; glcnacylation; e2f target ... See more keywords
FOXK1 regulates Wnt signaling to promote cardiogenesis.
Sign Up to like & getrecommendations! Published in 2023 at "Cardiovascular research"
DOI: 10.1093/cvr/cvad054
Abstract: AIMS Congenital heart disease (CHD) is the most common genetic birth defect, which has considerable morbidity and mortality. We focused on deciphering key regulators that govern cardiac progenitors and cardiogenesis. FOXK1 is a forkhead/winged helix… read more here.
Keywords: cardiogenesis; signaling promote; cardiogenesis foxk1; foxk1 ... See more keywords
miR‐144‐3p represses hepatocellular carcinoma progression by affecting cell aerobic glycolysis via FOXK1
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Experimental Pathology"
DOI: 10.1111/iep.12468
Abstract: Aerobic glycolysis is a unique mark of cancer cells, which enables therapeutic intervention in cancer. Forkhead box K1 (FOXK1) is a transcription factor that facilitates the progression of multiple cancers including hepatocellular carcinoma (HCC). Nevertheless,… read more here.
Keywords: cell; hcc; progression; foxk1 ... See more keywords
Abstract We032: FOXK1-Gli2 network regulates cardiomyocyte proliferation and heart regeneration
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.we032
Abstract: Unlike adult mammals, the neonatal mouse has an exceptional regenerative capacity following myocardial injury. Our goal was to decipher and define novel factors and mechanisms that have a role in regeneration of the injured adult… read more here.
Keywords: mck foxk1; heart; foxk1; gli2 ... See more keywords
Repression of lncRNA PART1 attenuates ovarian cancer cell viability, migration and invasion through the miR-503-5p/FOXK1 axis
Sign Up to like & getrecommendations! Published in 2022 at "BMC Cancer"
DOI: 10.1186/s12885-021-09005-x
Abstract: Background Ovarian cancer (OC) is a female malignant tumor with a high fatality rate. Long non-coding RNAs (lncRNAs) are deeply involved in OC progression. The aim of this study is to explore the specific mechanism… read more here.
Keywords: part1; foxk1; cell viability; viability migration ... See more keywords
FOXK1, Regulated by miR-365-3p, Promotes Cell Growth and EMT Indicates Unfavorable Prognosis in Breast Cancer
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s212702
Abstract: Background Forkhead box K1 (FOXK1) is members of the FOX transcription factor family. Previous work has found out that FOXK1 promotes cell proliferation, migration and invasion in several cancers, such as gastric cancer, glioma cancer… read more here.
Keywords: foxk1; mir 365; cancer; promotes cell ... See more keywords
Knockdown of circ-PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR-429/FOXK1 signaling axis
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12323
Abstract: Lung cancer is one of the most prevalent cancers in China, and its incidence and morbidity remain high due to various independent factors. Lung adenocarcinoma (ADC) is the most common type of non-small cell lung… read more here.
Keywords: circ pvt1; mir 429; pvt1; foxk1 ... See more keywords