Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12443
Abstract: Forkhead box transcription factor M1 (FOXM1) is a proliferation‐associated transcription factor involved in tumorigenesis through transcriptional regulation of its target genes in various cells, including dendritic cells (DCs). Although previous work has shown that FOXM1… read more here.
Keywords: foxm1; cancer colon; pancreatic cancer; colon cancer ... See more keywords
Novel benzothiazole/benzothiazole thiazolidine‐2,4‐dione derivatives as potential FOXM1 inhibitors: In silico, synthesis, and in vitro studies
Sign Up to like & getrecommendations! Published in 2024 at "Archiv Der Pharmazie"
DOI: 10.1002/ardp.202400504
Abstract: The oncogenic transcription factor FOXM1 overexpressed in breast and other solid cancers, is a key driver of tumor growth and progression through complex interactions, making it an attractive molecular target for the development of targeted… read more here.
Keywords: vitro studies; novel benzothiazole; foxm1 inhibitors; foxm1 ... See more keywords
FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.11.014
Abstract: Docetaxel-mediated chemotherapy is the first line therapy for metastatic castration-resistant prostate cancer (CRPC) patients, but its therapeutic benefit is limited by the development of resistance. Although Forkhead box protein M1 (FOXM1) has been implicated in… read more here.
Keywords: foxm1; resistance; castration resistant; cancer ... See more keywords
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.02.013
Abstract: The dynamic and reversible N6-methyladenosine (m6A) RNA modification installed and erased by N6-methyltransferases and demethylases regulates gene expression and cell fate. We show that the m6A demethylase ALKBH5 is highly expressed in glioblastoma stem-like cells… read more here.
Keywords: foxm1; expression cell; glioblastoma; alkbh5 ... See more keywords
MicroRNA profiling identifies Forkhead transcription factor M1 (FOXM1) regulated miR-186 and miR-200b alterations in triple negative breast cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109979
Abstract: Breast cancer (BC) is the most commonly diagnosed malignancy. MicroRNAs (miRNAs) play important roles in the tumorigenesis, metastasis and progression of BC. Forkhead Box M1 (FOXM1) oncogenic transcription factor is involved in events considered as… read more here.
Keywords: foxm1; mir 200b; breast cancer; cancer ... See more keywords
Knockdown of FOXM1 inhibits activation of keloid fibroblasts and extracellular matrix production via inhibition of TGF-β1/Smad pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116637
Abstract: Keloid is characterized by overactive fibroblasts. Forkhead box M1 (FOXM1) is transcription factor that plays important roles in the progression of fibrosis. However, the role of FOXM1 in keloid has not been elucidated. In the… read more here.
Keywords: foxm1; tgf; tgf induced; keloid fibroblasts ... See more keywords
GTSE1 promotes prostate cancer cell proliferation via the SP1/FOXM1 signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Laboratory Investigation"
DOI: 10.1038/s41374-020-00510-4
Abstract: G2 and S phase-expressed-1 (GTSE1) has been implicated in the pathogenesis of several malignant tumors. However, its specific role in prostate cancer (PCa) remains unclear. In this study, RNA-Seq data from patients with PCa and… read more here.
Keywords: foxm1; cell proliferation; prostate cancer; cancer ... See more keywords
Aberrantly high activation of a FoxM1–STMN1 axis contributes to progression and tumorigenesis in FoxM1-driven cancers
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00396-0
Abstract: Fork-head box protein M1 (FoxM1) is a transcriptional factor which plays critical roles in cancer development and progression. However, the general regulatory mechanism of FoxM1 is still limited. STMN1 is a microtubule-binding protein which can… read more here.
Keywords: foxm1; axis contributes; stmn1 axis; cancer ... See more keywords
ABL1-mediated phosphorylation promotes FOXM1-related tumorigenicity by Increasing FOXM1 stability
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-024-01339-w
Abstract: The transcription factor FOXM1, which plays critical roles in cell cycle progression and tumorigenesis, is highly expressed in rapidly proliferating cells and various tumor tissues, and high FOXM1 expression is related to a poor prognosis.… read more here.
Keywords: high foxm1; phosphorylation; foxm1 expression; foxm1 ... See more keywords
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-01929-0
Abstract: Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance and less good patient survival. The chemotherapy options for patients with the most aggressive types of solid cancers… read more here.
Keywords: foxm1 inhibitor; cancer; human cancers; cancer therapies ... See more keywords
Downreguation of FoxM1 by miR-214 inhibits proliferation and migration in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Gene Therapy"
DOI: 10.1038/s41434-018-0029-4
Abstract: The FoxM1 transcription factor plays an important role in the progression of HCC. Therefore, it is necessary to study cell regulation of FoxM1. In this study, we determined the expression of miR-214 and it was… read more here.
Keywords: inhibits proliferation; foxm1; proliferation migration; mir 214 ... See more keywords