KIAA1429 increases FOXM1 expression through YTHDF1–mediated m6A modification to promote aerobic glycolysis and tumorigenesis in multiple myeloma
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09904-2
Abstract: Multiple myeloma (MM) is a deadly plasma cell malignancy with elusive pathogenesis. N6-methyladenosine (m6A) is critically engaged in hematological malignancies. The function of KIAA1429, the largest component of methyltransferases, is unknown. This study delved into… read more here.
Keywords: aerobic glycolysis; ythdf1; kiaa1429 knockdown; foxm1 expression ... See more keywords
Abrogation of B-RafV600E induced senescence by FoxM1 expression.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.144
Abstract: B-RafV600E oncogene mutation occurs in various cancers and is associated with tumor initiation. However, genetic modification of B-RafV600E in cells induces MAPK activation and results in oncogene-induced senescence. Overcoming the oncogene-induced senescence by B-RafV600E requires… read more here.
Keywords: foxm1 expression; rafv600e; induced senescence; senescence ... See more keywords
High glucose upregulates FOXM1 expression via EGFR/STAT3 dependent activation to promote progression of cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119114
Abstract: AIMS Epidemiological studies indicate diabetes mellitus and hyperglycemia as risk factors of cancers including cholangiocarcinoma (CCA). How high glucose promotes cancer development and progression, however, is still unrevealed. In this study, insight into the molecular… read more here.
Keywords: high glucose; foxm1 expression; expression; activation ... See more keywords
ABL1-mediated phosphorylation promotes FOXM1-related tumorigenicity by Increasing FOXM1 stability
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DOI: 10.1038/s41418-024-01339-w
Abstract: The transcription factor FOXM1, which plays critical roles in cell cycle progression and tumorigenesis, is highly expressed in rapidly proliferating cells and various tumor tissues, and high FOXM1 expression is related to a poor prognosis.… read more here.
Keywords: high foxm1; phosphorylation; foxm1 expression; foxm1 ... See more keywords
Combining KPNA2 and FOXM1 Expression as Prognostic Markers and Therapeutic Targets in Hormone Receptor-Positive, HER2-Negative Breast Cancer
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DOI: 10.3390/cancers17040671
Abstract: Simple Summary Breast cancer affects millions worldwide, with the hormone receptor-positive, HER2-negative (HR+HER2-) type being the most common form. Our study investigated the prognostic significance of FOXM1 expression specifically in HR+HER2- breast cancer patients with… read more here.
Keywords: expression; her2; breast cancer; foxm1 expression ... See more keywords