Caffeine supplementation and FOXM1 inhibition enhance the antitumor effect of statins in neuroblastoma.
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DOI: 10.1158/0008-5472.can-22-3450
Abstract: High-risk neuroblastoma exhibits transcriptional activation of the mevalonate pathway that produces cholesterol and non-sterol isoprenoids. A better understanding of how this metabolic reprogramming contributes to neuroblastoma development could help identify potential prevention and treatment strategies.… read more here.
Keywords: foxm1 inhibition; caffeine; mevalonate pathway;