FOXO acts as a positive regulator of CncC and deltamethrin tolerance in the red flour beetle, Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6811
Abstract: BACKGROUND Both forkhead box O (FOXO) and nuclear factor erythroid-derived 2-like-2 (Nrf2) are key transcription factors related to stress response. While limited studies in mammals and Caenorhabditis elegans revealed interaction between FoxO/DAF-16 and Nrf2/SKN-1, the… read more here.
Keywords: cncc; tribolium castaneum; deltamethrin; foxo ... See more keywords
20-hydroxyecdysone regulates expression of methioninesulfoxide reductases through transcription factor FOXO in the red flour beetle, Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2021 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2021.103546
Abstract: The oxidation of methionine (Met) by reactive oxygen species (ROS) causes detrimental effects on the protein functions. Methionine sulfoxide reductase (Msr) is the secondary antioxidant enzyme involved in protein repair, and is divided into two… read more here.
Keywords: red flour; msra; foxo; msra msrb ... See more keywords
Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2018.05.008
Abstract: Japanese encephalitis virus (JEV) infection induces brain tissue disease characterized by neuron death. however, little is known about the underlying mechanism. Using RNA sequencing, we profiled global mRNA expression changes in response to in vitro… read more here.
Keywords: foxo; jev; apoptosis; jev infection ... See more keywords
FoxO mediates the timing of pupation through regulating ecdysteroid biosynthesis in the red flour beetle, Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.05.012
Abstract: The steroid hormone 20-hydroxyecdysone (20E), the major developmental hormone in insects, controls all the developmental transitions including ecdysis and metamorphosis. In our study with last larval stages of the red flour beetle, Tribolium castaneum, dsRNA-mediated… read more here.
Keywords: red flour; foxo; pupation; ecdysteroid biosynthesis ... See more keywords
Two Point Mutations in CYP4CE1 Promoter Contributed to the Differential Regulation of CYP4CE1 Expression by FoxO between Susceptible and Nitenpyram-Resistant Nilaparvata lugens.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.3c02495
Abstract: Four P450s were reported to be important for imidacloprid resistance in Nilaparvata lugens, a major insect pest on rice, which was confirmed in this study in an imidacloprid-resistant strain (ImiR). Here we found that only… read more here.
Keywords: cyp4ce1 promoter; foxo; cyp4ce1 expression; cyp4ce1 ... See more keywords
MicroRNA miR‐2765‐3p regulates reproductive diapause by targeting FoxO in Galeruca daurica
Sign Up to like & getrecommendations! Published in 2022 at "Insect Science"
DOI: 10.1111/1744-7917.13089
Abstract: The forkhead box O (FoxO), as a conserved transcription factor, plays an indispensable role in regulating insect diapause. However, how FoxO is regulated to control diapause in insects remains unknown. In this study, we discovered… read more here.
Keywords: diapause; reproductive diapause; foxo; daurica ... See more keywords
FoxO is required for optimal fitness of the migratory brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae).
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13163
Abstract: The forkhead box O (FoxO) protein is the main transcriptional effector downstream of the insulin/insulin-like signaling pathway and regulates many developmental and physiological processes. Holometabolous insects with loss-of-function mutations in FoxO exhibit phenotypes distinct from… read more here.
Keywords: nilaparvata lugens; insects; required optimal; foxo ... See more keywords
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12800
Abstract: Intervertebral disk (IVD) degeneration is a prevalent age‐associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis… read more here.
Keywords: homeostasis; intervertebral disk; foxo; homeostasis aging ... See more keywords
Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/5694223
Abstract: Cisplatin (DDP), a widely used chemotherapeutic drug in cancer treatment, causes oxidative stress, resulting in cancer cachexia and skeletal muscle atrophy. This study investigated the effects and activity of silibinin (SLI) in reducing DDP-induced oxidative… read more here.
Keywords: muscle atrophy; foxo; oxidative stress;
Role of the Transcription Factor FoxO in Type 2 Diabetes and Its Complications.
Sign Up to like & getrecommendations! Published in 2025 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2025057309
Abstract: FoxO proteins represent a subfamily of the forkhead box family (Fox) superfamily of proteins. It is involved in cell proliferation, differentiation, oxidative stress, apoptosis as well as tumors and metabolic disorders by regulating cellular functions.… read more here.
Keywords: diabetes complications; transcription factor; role; foxo ... See more keywords
The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Current pharmaceutical design"
DOI: 10.2174/1381612824666180911114210
Abstract: The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and play a vital role in various cellular and physiological processes include for instance, ROS (reactive oxygen species) response, cell proliferation, regulation… read more here.
Keywords: transcription; dual specificity; foxo; role ... See more keywords