FOXO acts as a positive regulator of CncC and deltamethrin tolerance in the red flour beetle, Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6811
Abstract: BACKGROUND Both forkhead box O (FOXO) and nuclear factor erythroid-derived 2-like-2 (Nrf2) are key transcription factors related to stress response. While limited studies in mammals and Caenorhabditis elegans revealed interaction between FoxO/DAF-16 and Nrf2/SKN-1, the… read more here.
Keywords: cncc; tribolium castaneum; deltamethrin; foxo ... See more keywords
20-hydroxyecdysone regulates expression of methioninesulfoxide reductases through transcription factor FOXO in the red flour beetle, Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2021 at "Insect biochemistry and molecular biology"
DOI: 10.1016/j.ibmb.2021.103546
Abstract: The oxidation of methionine (Met) by reactive oxygen species (ROS) causes detrimental effects on the protein functions. Methionine sulfoxide reductase (Msr) is the secondary antioxidant enzyme involved in protein repair, and is divided into two… read more here.
Keywords: red flour; msra; foxo; msra msrb ... See more keywords
Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary microbiology"
DOI: 10.1016/j.vetmic.2018.05.008
Abstract: Japanese encephalitis virus (JEV) infection induces brain tissue disease characterized by neuron death. however, little is known about the underlying mechanism. Using RNA sequencing, we profiled global mRNA expression changes in response to in vitro… read more here.
Keywords: foxo; jev; apoptosis; jev infection ... See more keywords
FoxO mediates the timing of pupation through regulating ecdysteroid biosynthesis in the red flour beetle, Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2017.05.012
Abstract: The steroid hormone 20-hydroxyecdysone (20E), the major developmental hormone in insects, controls all the developmental transitions including ecdysis and metamorphosis. In our study with last larval stages of the red flour beetle, Tribolium castaneum, dsRNA-mediated… read more here.
Keywords: red flour; foxo; pupation; ecdysteroid biosynthesis ... See more keywords
MicroRNA miR‐2765‐3p regulates reproductive diapause by targeting FoxO in Galeruca daurica
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DOI: 10.1111/1744-7917.13089
Abstract: The forkhead box O (FoxO), as a conserved transcription factor, plays an indispensable role in regulating insect diapause. However, how FoxO is regulated to control diapause in insects remains unknown. In this study, we discovered… read more here.
Keywords: diapause; reproductive diapause; foxo; daurica ... See more keywords
FoxO is required for optimal fitness of the migratory brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae).
Sign Up to like & getrecommendations! Published in 2022 at "Insect science"
DOI: 10.1111/1744-7917.13163
Abstract: The forkhead box O (FoxO) protein is the main transcriptional effector downstream of the insulin/insulin-like signaling pathway and regulates many developmental and physiological processes. Holometabolous insects with loss-of-function mutations in FoxO exhibit phenotypes distinct from… read more here.
Keywords: nilaparvata lugens; insects; required optimal; foxo ... See more keywords
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration
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DOI: 10.1111/acel.12800
Abstract: Intervertebral disk (IVD) degeneration is a prevalent age‐associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis… read more here.
Keywords: homeostasis; intervertebral disk; foxo; homeostasis aging ... See more keywords
Silibinin Alleviates Muscle Atrophy Caused by Oxidative Stress Induced by Cisplatin through ERK/FoxO and JNK/FoxO Pathways
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DOI: 10.1155/2022/5694223
Abstract: Cisplatin (DDP), a widely used chemotherapeutic drug in cancer treatment, causes oxidative stress, resulting in cancer cachexia and skeletal muscle atrophy. This study investigated the effects and activity of silibinin (SLI) in reducing DDP-induced oxidative… read more here.
Keywords: muscle atrophy; foxo; oxidative stress;
The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer.
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DOI: 10.2174/1381612824666180911114210
Abstract: The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and play a vital role in various cellular and physiological processes include for instance, ROS (reactive oxygen species) response, cell proliferation, regulation… read more here.
Keywords: transcription; dual specificity; foxo; role ... See more keywords
ceRNA Network Regulation of TGF-β, WNT, FOXO, Hedgehog Pathways in the Pharynx of Ciona robusta
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DOI: 10.3390/ijms22073497
Abstract: The transforming growth factor-β (TGF-β) family of cytokines performs a multifunctional signaling, which is integrated and coordinated in a signaling network that involves other pathways, such as Wintless, Forkhead box-O (FOXO) and Hedgehog and regulates… read more here.
Keywords: cin; foxo; hedgehog; cin mir ... See more keywords
mTORC2 Is the Major Second Layer Kinase Negatively Regulating FOXO3 Activity
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175414
Abstract: Forkhead box O (FOXO) proteins are transcription factors involved in cancer and aging and their pharmacological manipulation could be beneficial for the treatment of cancer and healthy aging. FOXO proteins are mainly regulated by post-translational… read more here.
Keywords: foxo; kinase; foxo3 activity; second layer ... See more keywords