Role of FoxO Proteins in Cellular Response to Antitumor Agents
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DOI: 10.3390/cancers11010090
Abstract: FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 and FoxO6), with redundant activity, exhibit mainly a positive… read more here.
Keywords: response antitumor; response; drug; role ... See more keywords
MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells
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DOI: 10.3390/cancers14184482
Abstract: Simple Summary We have investigated the transcriptional changes occurring in uveal and cutaneous melanoma cell lines upon depletion of MDMX (aka:MDM4). Computational analyses of the mRNAs/genes affected upon MDMX depletion determined that many were containing… read more here.
Keywords: cell; melanoma; activity; p53 ... See more keywords