Loss of FOXO transcription factors in the liver mitigates stress-induced hyperglycemia
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2021.101246
Abstract: Objective Stress-induced hyperglycemia is associated with poor outcomes in nearly all critical illnesses. This acute elevation in glucose after injury or illness is associated with increased morbidity and mortality, including multiple organ failure. Stress-induced hyperglycemia… read more here.
Keywords: induced hyperglycemia; stress induced; hyperglycemia; transcription factors ... See more keywords
FoxO transcription factors in mitochondrial homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210777
Abstract: Mitochondria play essential roles in cellular energetics, biosynthesis, and signaling transduction. Dysfunctional mitochondria have been implicated in different diseases such as obesity, diabetes, cardiovascular disease, nonalcoholic fatty liver disease, neurodegenerative disease, and cancer. Mitochondrial homeostasis… read more here.
Keywords: homeostasis; factors mitochondrial; foxo transcription; transcription factors ... See more keywords
Targeting FoxO transcription factors with HDAC inhibitors for the treatment of osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/ard-2021-221269
Abstract: Objectives Osteoarthritis (OA) features ageing-related defects in cellular homeostasis mechanisms in articular cartilage. These defects are associated with suppression of forkhead box O (FoxO) transcription factors. FoxO1 or FoxO3 deficient mice show early onset OA… read more here.
Keywords: expression; factors hdac; transcription factors; foxo transcription ... See more keywords
FOXO transcription factors are required for normal somatotrope function and growth.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology"
DOI: 10.1210/endocr/bqab263
Abstract: Understanding the molecular mechanisms underlying pituitary organogenesis and function is essential for improving therapeutics and molecular diagnoses for hypopituitarism. We previously found that deletion of the forkhead factor, Foxo1, in the pituitary gland early in… read more here.
Keywords: expression; somatotrope function; function; foxo transcription ... See more keywords
Loss of Insulin/IGF-1 Receptors in Muscle Coordinately Downregulates Mitochondrial Metabolism and Alters Mitophagy via Foxo Transcription Factors
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DOI: 10.2337/db18-187-or
Abstract: Diabetes is associated with decreased muscle strength and energy production. There is a strong association between muscle insulin resistance and mitochondrial abnormalities, but cause/effect remains hotly debated. Recently, we showed that insulin receptor (IR) and… read more here.
Keywords: insulin; metabolism; muscle; alters mitophagy ... See more keywords