Protective mechanism of FoxO1 against early brain injury after subarachnoid hemorrhage by regulating autophagy.
Sign Up to like & getrecommendations! Published in 2021 at "Brain and behavior"
DOI: 10.1002/brb3.2376
Abstract: INTRODUCTION Early brain injury (EBI) plays a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). Autophagy and apoptosis may share a common molecular inducer that regulates the process of cell death. FoxO1, as… read more here.
Keywords: early brain; foxo1; brain; function ... See more keywords
MiRNA‐1271‐5p regulates osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells by targeting forkhead box O1 (FOXO1)
Sign Up to like & getrecommendations! Published in 2021 at "Cell Biology International"
DOI: 10.1002/cbin.11585
Abstract: Forkhead box O1 (FOXO1) is a key regulator of osteogenesis. The aim of this study was to identify the mechanisms of microRNAs (miRNAs) targeting FOXO1 in osteogenic differentiation of human bone marrow mesenchymal stem cells… read more here.
Keywords: foxo1; bone; expression; osteogenic differentiation ... See more keywords
FOXO1 is downregulated in obese mice subjected to short‐term strength training
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30882
Abstract: Obesity is a worldwide health problem and is directly associated with insulin resistance and type 2 diabetes. The liver is an important organ for the control of healthy glycemic levels, since insulin resistance in this… read more here.
Keywords: strength; strength training; term strength; foxo1 ... See more keywords
PHLPP1/Nrf2-Mdm2 axis induces renal apoptosis via influencing nucleo-cytoplasmic shuttling of FoxO1 during diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and cellular biochemistry"
DOI: 10.1007/s11010-021-04177-3
Abstract: Impaired PI3K/Akt signaling (insulin resistance) and poor glycemic control (hyperglycemia) are the major risk factors involved in the progression of diabetic nephropathy (DN). This study was designed to identify factors influencing cell survival during DN.… read more here.
Keywords: phlpp1; apoptosis; mdm2; foxo1 ... See more keywords
Therapeutic effects of Chlorella vulgaris on carbon tetrachloride induced liver fibrosis by targeting Hippo signaling pathway and AMPK/FOXO1 axis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05978-3
Abstract: This study was conducted to present the mechanism of the therapeutic effects of Chlorella vulgaris extract (CV) on the carbon tetrachloride (CCl4) induced liver fibrosis model. Primarily, the mechanism of antioxidant effects of CV were… read more here.
Keywords: protein; chlorella vulgaris; treatment; foxo1 ... See more keywords
MiR-181c restrains nitration stress of endothelial cells in diabetic db/db mice through inhibiting the expression of FoxO1.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.083
Abstract: Endothelial dysfunction played an important role in the progression of diabetes mellitus (DM). miR-181c has been implicated in many diseases, including DM. However, the molecular mechanisms of miR-181c regulate this process remained poorly understood. Healthy… read more here.
Keywords: foxo1; mir 181c; expression; endothelial cells ... See more keywords
FoxO1 controls the expansion of pre-B cells by regulating the expression of interleukin 7 receptor α chain and its signal pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Immunology letters"
DOI: 10.1016/j.imlet.2019.09.004
Abstract: Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using… read more here.
Keywords: expansion pre; expansion; foxo1; expression ... See more keywords
Imaging flow cytometry: A method for examining dynamic native FOXO1 localization in human lymphocytes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2018.01.001
Abstract: While flow cytometry can reliably assess surface and intracellular marker expression within small cell populations, it does not provide any information on protein localization. Several key transcription factors (TF) downstream of lymphocyte surface receptors are… read more here.
Keywords: localization human; native foxo1; foxo1; foxo1 localization ... See more keywords
Leptin suppresses microRNA‐122 promoter activity by phosphorylation of foxO1 in hepatic stellate cell contributing to leptin promotion of mouse liver fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.12.007
Abstract: &NA; Adipocytokine leptin promotes hepatic stellate cell (HSC) activation (a key step in liver fibrogenesis) and liver fibrosis. microRNA‐122 (miR‐122) is the most abundant liver‐specific miRNA and was demonstrated to inhibit liver fibrosis and reduced… read more here.
Keywords: liver fibrosis; 122 promoter; leptin; foxo1 ... See more keywords
Physalin B reduces Aβ secretion by downregulating the expression of BACE1 via the activation of FoxO1 and the inhibition of STAT3 phosphorylation
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Journal of Natural Medicines"
DOI: 10.1016/s1875-5364(21)60090-0
Abstract: Physalin B (PB), one of the major active steroidal constituents of Solanaceae Physalis plants, has a wide variety of biological activities. We found that PB significantly downregulated β-amyloid (Aβ) secretions in N2a/APPsw cells. However, the… read more here.
Keywords: expression; expression bace1; phosphorylation; secretion ... See more keywords
Immunohistochemical detection of PAX-FOXO1 fusion proteins in alveolar rhabdomyosarcoma using breakpoint specific monoclonal antibodies
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-00719-0
Abstract: Alveolar Rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer with about 80% of cases characterized by either a t(1;13)(p36;q14) or t(2;13)(q35;q14), which results in the formation of the fusion oncogenes PAX7-FOXO1 and PAX3-FOXO1, respectively. Since patients… read more here.
Keywords: detection; foxo1; rhabdomyosarcoma; fusion ... See more keywords