Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity
Sign Up to like & getrecommendations! Published in 2022 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2022.101621
Abstract: Life expectancy has increased substantially over the last 150 years. Yet this means that now most people also spend a greater length of time suffering from various age-associated diseases. As such, delaying age-related functional decline… read more here.
Keywords: healthspan; nutraceutical activation; pharmaceutical nutraceutical; longevity ... See more keywords
O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0366-1
Abstract: The leading cause of death in cancer patients is metastasis, for which an effective treatment is still necessary. During metastasis, cancer cells aberrantly express several glycans that are correlated with poor patient outcome. This study… read more here.
Keywords: foxo3; cholangiocarcinoma; cca; metastasis ... See more keywords
LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1321-5
Abstract: Aberrant expression of laminin-332 promotes tumour growth and metastasis in multiple cancers. However, the dysregulated expression and mechanism of action of LAMB3, which encodes the β3 subunit of laminin-332, and the mechanism underlying dysregulated LAMB3… read more here.
Keywords: foxo3; elk4; brd2; expression ... See more keywords
TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1556946
Abstract: ABSTRACT Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and inflammation, as well as metabolism and cell survival. Diverse immune and… read more here.
Keywords: capacity microglia; toll like; autophagy inhibition; foxo3 ... See more keywords
Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2034567
Abstract: ABSTRACT The expression of circRNA_FOXO3 was found to be positively associated with the expression of Forkhead Box O3 (FOXO3), which is targeted and regulated by miR-23a. Polymorphisms in rs12196996 and rs2232365 have been reported in… read more here.
Keywords: polymorphism; acquired sepsis; circrna foxo3; foxo3 ... See more keywords
Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2021/3830671
Abstract: Polygonum cuspidatum (PC) has been reported to exert a potent antihyperlipidemic effect. However, its mechanisms of action and active ingredients remain elusive and require further research. In this study, we first conducted in vivo experiments… read more here.
Keywords: cuspidatum extract; polygonum cuspidatum; foxo3; signaling pathway ... See more keywords
Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7727616
Abstract: Oxidative stress and neuronal apoptosis contribute to pathological processes of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies demonstrated that the inhibition of prostaglandin E2 receptor EP3 suppressed oxidative stress and apoptotic effects… read more here.
Keywords: ep3; oxidative stress; mul1; foxo3 ... See more keywords
FOXO3 Mediates Tooth Movement by Regulating Force-Induced Osteogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dental research"
DOI: 10.1177/00220345211021534
Abstract: The high prevalence of malocclusion and dentofacial malformations means that the demand for orthodontic treatments has been increasing rapidly. As the biological basis of orthodontic treatment, the mechanism of mechanical force-induced alveolar bone remodeling during… read more here.
Keywords: foxo3; force induced; tooth movement; mechanical force ... See more keywords
Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis
Sign Up to like & getrecommendations! Published in 2019 at "BMC Cancer"
DOI: 10.1186/s12885-019-6110-6
Abstract: BackgroundHepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription… read more here.
Keywords: akt; loop; foxo3; hepatocellular carcinogenesis ... See more keywords
Dental pulp mesenchymal stem cell-derived exosomes inhibit neuroinflammation and microglial pyroptosis in subarachnoid hemorrhage via the miRNA-197-3p/FOXO3 axis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-024-02708-w
Abstract: Subarachnoid hemorrhage (SAH) is a severe stroke subtype that lacks effective treatment. Exosomes derived from human dental pulp stem cells (DPSCs) are a promising acellular therapeutic strategy for neurological diseases. However, the therapeutic effects of… read more here.
Keywords: foxo3; mir 197; dpsc exos; sah ... See more keywords
Polymorphism of the Forkhead box-O3 (FOXO3) Longevity Gene rs2802292 and senescence-associated secretory phenotype (SASP) in Indonesian Elderly Population
Sign Up to like & getrecommendations! Published in 2024 at "Nutrition and Healthy Aging"
DOI: 10.3233/nha-231516
Abstract: BACKGROUND: Forkhead box O3 (FOXO3) is a transcription factor that regulates stress resistance, metabolism, cell cycle, and apoptosis. Several studies exhibited the association of the FOXO3 polymorphism rs2802292 with human longevity and protects individuals from… read more here.
Keywords: foxo3; polymorphism; indonesian elderly; sasp ... See more keywords