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   Articles with "foxo3" as a keyword



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Pharmaceutical and nutraceutical activation of FOXO3 for healthy longevity

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recommendations! Published in 2022 at "Ageing Research Reviews"

DOI: 10.1016/j.arr.2022.101621

Abstract: Life expectancy has increased substantially over the last 150 years. Yet this means that now most people also spend a greater length of time suffering from various age-associated diseases. As such, delaying age-related functional decline… read more here.

Keywords: healthspan; nutraceutical activation; pharmaceutical nutraceutical; longevity ... See more keywords

O-GlcNAcylation mediates metastasis of cholangiocarcinoma through FOXO3 and MAN1A1

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recommendations! Published in 2018 at "Oncogene"

DOI: 10.1038/s41388-018-0366-1

Abstract: The leading cause of death in cancer patients is metastasis, for which an effective treatment is still necessary. During metastasis, cancer cells aberrantly express several glycans that are correlated with poor patient outcome. This study… read more here.

Keywords: foxo3; cholangiocarcinoma; cca; metastasis ... See more keywords

LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer

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recommendations! Published in 2020 at "Oncogene"

DOI: 10.1038/s41388-020-1321-5

Abstract: Aberrant expression of laminin-332 promotes tumour growth and metastasis in multiple cancers. However, the dysregulated expression and mechanism of action of LAMB3, which encodes the β3 subunit of laminin-332, and the mechanism underlying dysregulated LAMB3… read more here.

Keywords: foxo3; elk4; brd2; expression ... See more keywords
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TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

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recommendations! Published in 2019 at "Autophagy"

DOI: 10.1080/15548627.2018.1556946

Abstract: ABSTRACT Macroautophagy/autophagy is a lysosome-dependent catabolic process for the turnover of proteins and organelles in eukaryotes. Autophagy plays an important role in immunity and inflammation, as well as metabolism and cell survival. Diverse immune and… read more here.

Keywords: capacity microglia; toll like; autophagy inhibition; foxo3 ... See more keywords

Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2034567

Abstract: ABSTRACT The expression of circRNA_FOXO3 was found to be positively associated with the expression of Forkhead Box O3 (FOXO3), which is targeted and regulated by miR-23a. Polymorphisms in rs12196996 and rs2232365 have been reported in… read more here.

Keywords: polymorphism; acquired sepsis; circrna foxo3; foxo3 ... See more keywords
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Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway

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recommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2021/3830671

Abstract: Polygonum cuspidatum (PC) has been reported to exert a potent antihyperlipidemic effect. However, its mechanisms of action and active ingredients remain elusive and require further research. In this study, we first conducted in vivo experiments… read more here.

Keywords: cuspidatum extract; polygonum cuspidatum; foxo3; signaling pathway ... See more keywords
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Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/7727616

Abstract: Oxidative stress and neuronal apoptosis contribute to pathological processes of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies demonstrated that the inhibition of prostaglandin E2 receptor EP3 suppressed oxidative stress and apoptotic effects… read more here.

Keywords: ep3; oxidative stress; mul1; foxo3 ... See more keywords
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FOXO3 Mediates Tooth Movement by Regulating Force-Induced Osteogenesis.

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recommendations! Published in 2021 at "Journal of dental research"

DOI: 10.1177/00220345211021534

Abstract: The high prevalence of malocclusion and dentofacial malformations means that the demand for orthodontic treatments has been increasing rapidly. As the biological basis of orthodontic treatment, the mechanism of mechanical force-induced alveolar bone remodeling during… read more here.

Keywords: foxo3; force induced; tooth movement; mechanical force ... See more keywords
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Oncogenic Akt-FOXO3 loop favors tumor-promoting modes and enhances oxidative damage-associated hepatocellular carcinogenesis

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recommendations! Published in 2019 at "BMC Cancer"

DOI: 10.1186/s12885-019-6110-6

Abstract: BackgroundHepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic cell proliferation and survival. Key transcription… read more here.

Keywords: akt; loop; foxo3; hepatocellular carcinogenesis ... See more keywords
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Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway

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recommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"

DOI: 10.3389/fbioe.2020.615850

Abstract: Background Acute myocardial infarction (AMI) is one of the leading causes of morbidity and death worldwide. Studies have indicated that microRNAs in mesenchymal stem cell (MSC)-derived exosomes are crucial for treating various diseases. Methods Human… read more here.

Keywords: hypoxia reoxygenation; umbilical cord; pyroptosis; foxo3 ... See more keywords

Potential Cytoprotective and Regulatory Effects of Ergothioneine on Gene Expression of Proteins Involved in Erythroid Adaptation Mechanisms and Redox Pathways in K562 Cells

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recommendations! Published in 2022 at "Genes"

DOI: 10.3390/genes13122368

Abstract: This study aimed to establish the importance of ergothioneine (ERT) in the erythroid adaptation mechanisms by appraising the expression levels of redox-related genes associated with the PI3K/AKT/FoxO3 and Nrf2-ARE pathways using K562 cells induced to… read more here.

Keywords: k562 cells; expression; gene expression; adaptation mechanisms ... See more keywords