Liraglutide provides neuroprotection by regulating autophagy through the AMPK-FOXO3 signaling pathway in a spinal contusion injury rat model
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134747
Abstract: Spinal cord injury (SCI) induced by trauma is a devasting neurological consequences. Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, has be shown to have neuroprotective effects in several neurodegenerative diseases. However, the potential benefits of liraglutide… read more here.
Keywords: ampk foxo3; spinal contusion; contusion; foxo3 signaling ... See more keywords
Activation of the Akt/FoxO3 signaling pathway enhances oxidative stress-induced autophagy and alleviates brain damage in a rat model of ischemic stroke.
Sign Up to like & getrecommendations! Published in 2022 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2022-0341
Abstract: Autophagy has been implicated in stroke. Our previous study showed that the FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion (I/R). However, whether the Akt/FoxO3 signaling pathway plays a regulatory role in autophagy in… read more here.
Keywords: signaling pathway; oxidative stress; akt foxo3; foxo3 signaling ... See more keywords