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   Articles with "foxo3a" as a keyword



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FOXO3a is essential for murine endometrial decidualization through cell apoptosis during early pregnancy

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27167

Abstract: Embryo implantation is essential for normal pregnancy, and the process of decidualization is critical for embryo implantation. However, the mechanism of decidualization during early pregnancy is still unknown. Forkhead box O3a (FOXO3a) is the most… read more here.

Keywords: decidualization; cell apoptosis; foxo3a; early pregnancy ... See more keywords
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Forkhead box o3a suppresses lipopolysaccharide‐stimulated proliferation and inflammation in fibroblast‐like synoviocytes through regulating tripartite motif‐containing protein 3

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28615

Abstract: Fibroblast‐like synoviocytes (FLS), synovial tissue‐specific cells, are key effector cells during the pathogenesis of rheumatoid arthritis (RA). Our previous study has shown that tripartite motif‐containing protein 3 (TRIM3) overexpression inhibits the proliferation and cytokine secretion… read more here.

Keywords: foxo3a trim3; fibroblast like; like synoviocytes; foxo3a ... See more keywords
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Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a.

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recommendations! Published in 2021 at "Journal of cellular physiology"

DOI: 10.1002/jcp.30532

Abstract: Maternal aging can impair the quality and decrease the developmental competence of ovulated oocytes. In this study, compromised germinal vesicle breakdown (GVBD) was found in aged mice oocytes. Furthermore, we observed increased reactive oxygen species… read more here.

Keywords: mitochondrial function; foxo3a; affects mitochondrial; nampt affects ... See more keywords
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SH‐PRO extract alleviates benign prostatic hyperplasia via ROS‐mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA signaling in vitro and in vivo

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7626

Abstract: To target benign prostatic hyperplasia (BPH) as a common urinary disease in old men, in the current study, the antiproliferative and apoptotic mechanism of SH‐PRO, a mixture of Angelica gigas and Astragalus membranaceus (2:1), was… read more here.

Keywords: bph; foxo3a; psa; bph cells ... See more keywords
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The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats

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recommendations! Published in 2020 at "Cell Stress and Chaperones"

DOI: 10.1007/s12192-020-01170-5

Abstract: Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats.… read more here.

Keywords: stz induced; induced diabetic; tropisetron; foxo3a ... See more keywords
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The tumor suppressor FOXO3a mediates the response to EGFR inhibition in glioblastoma cells

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recommendations! Published in 2019 at "Cellular Oncology"

DOI: 10.1007/s13402-019-00443-1

Abstract: PurposeAlthough EGFR activation is a hallmark of glioblastoma (GBM), anti-EGFR therapy has so far not yielded the desired effects. Targeting PI3K/Akt has been proposed as a strategy to increase the cellular sensitivity to EGFR inhibitors.… read more here.

Keywords: response; gbm; foxo3a; egfr inhibition ... See more keywords
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FOXO3a Reverses the Cisplatin Resistance in Ovarian Cancer.

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recommendations! Published in 2018 at "Archives of medical research"

DOI: 10.1016/j.arcmed.2018.04.014

Abstract: OBJECTIVE Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the… read more here.

Keywords: resistance ovarian; foxo3a; drug; ovarian cancer ... See more keywords
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Ellagic acid protects rats from chronic renal failure via MiR-182/FOXO3a axis.

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recommendations! Published in 2021 at "Molecular immunology"

DOI: 10.1016/j.molimm.2021.08.007

Abstract: Studies showed that ellagic acid (EA) can significantly improve kidney function, but the renal-protective effects of EA and the potential mechanism require adequate elucidation. This study investigated the mechanisms of EA in chronic renal failure… read more here.

Keywords: renal failure; foxo3a; mir 182; chronic renal ... See more keywords
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miR-155-5p/FOXO3a promotes pulmonary fibrosis in rats by mediating NLRP3 inflammasome activation

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recommendations! Published in 2022 at "Immunopharmacology and Immunotoxicology"

DOI: 10.1080/08923973.2022.2115923

Abstract: Abstract Objective Pulmonary fibrosis (PF) is regarded as progressive lung disease. miR-155-5p depletion exerts anti-fibrotic effects in silicotic mice. This study explored the effect and possible mechanism of miR-155-5p in PF rats, hoping to find… read more here.

Keywords: mir 155; pulmonary fibrosis; foxo3a; nlrp3 asc ... See more keywords
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FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim.

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recommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"

DOI: 10.1093/abbs/gmaa129

Abstract: Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to improve cell sensitivity to chemotherapeutic drugs. The… read more here.

Keywords: cells cisplatin; foxo3a; non small; cell ... See more keywords
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Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway

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recommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.14406

Abstract: The damage of vascular endothelial cells induced by oxidative stress plays an important role in the pathogenesis of atherosclerosis. Dihydromyricetin (DMY) is considered as a natural antioxidant. However, the mechanism of DMY on endothelial cell… read more here.

Keywords: akt; induced sodium; foxo3a; oxidative damage ... See more keywords