Violaceoid F induces nuclear translocation of FOXO3a by inhibiting CRM1 via a novel mechanism and suppresses HeLa cell growth
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Letters"
DOI: 10.1002/1873-3468.15085
Abstract: FOXO3a is a transcription factor involved in cell growth inhibition and apoptosis. FOXO3a is localized in the cytoplasm in cancer cells, and its nuclear translocation by small molecules is expected to prevent cancer cell growth.… read more here.
Keywords: nuclear translocation; cell growth; foxo3a; crm1 ... See more keywords
Inhibition of phosphodiesterase 4 attenuates aquaporin 4 expression and astrocyte swelling following cerebral ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24572
Abstract: We have previously shown that phosphodiesterase 4 (PDE4) inhibition protects against neuronal injury in rats following middle cerebral artery occlusion/reperfusion (MCAO/R). However, the effects of PDE4 on brain edema and astrocyte swelling are unknown. In… read more here.
Keywords: brain; astrocyte swelling; inhibition; foxo3a ... See more keywords
FOXO3a is essential for murine endometrial decidualization through cell apoptosis during early pregnancy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27167
Abstract: Embryo implantation is essential for normal pregnancy, and the process of decidualization is critical for embryo implantation. However, the mechanism of decidualization during early pregnancy is still unknown. Forkhead box O3a (FOXO3a) is the most… read more here.
Keywords: decidualization; cell apoptosis; foxo3a; early pregnancy ... See more keywords
Forkhead box o3a suppresses lipopolysaccharide‐stimulated proliferation and inflammation in fibroblast‐like synoviocytes through regulating tripartite motif‐containing protein 3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28615
Abstract: Fibroblast‐like synoviocytes (FLS), synovial tissue‐specific cells, are key effector cells during the pathogenesis of rheumatoid arthritis (RA). Our previous study has shown that tripartite motif‐containing protein 3 (TRIM3) overexpression inhibits the proliferation and cytokine secretion… read more here.
Keywords: foxo3a trim3; fibroblast like; like synoviocytes; foxo3a ... See more keywords
Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30532
Abstract: Maternal aging can impair the quality and decrease the developmental competence of ovulated oocytes. In this study, compromised germinal vesicle breakdown (GVBD) was found in aged mice oocytes. Furthermore, we observed increased reactive oxygen species… read more here.
Keywords: mitochondrial function; foxo3a; affects mitochondrial; nampt affects ... See more keywords
SH‐PRO extract alleviates benign prostatic hyperplasia via ROS‐mediated activation of PARP/caspase 3 and inhibition of FOXO3a/AR/PSA signaling in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7626
Abstract: To target benign prostatic hyperplasia (BPH) as a common urinary disease in old men, in the current study, the antiproliferative and apoptotic mechanism of SH‐PRO, a mixture of Angelica gigas and Astragalus membranaceus (2:1), was… read more here.
Keywords: bph; foxo3a; psa; bph cells ... See more keywords
The effect of tropisetron on oxidative stress, SIRT1, FOXO3a, and claudin-1 in the renal tissue of STZ-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01170-5
Abstract: Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats.… read more here.
Keywords: stz induced; induced diabetic; tropisetron; foxo3a ... See more keywords
The tumor suppressor FOXO3a mediates the response to EGFR inhibition in glioblastoma cells
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DOI: 10.1007/s13402-019-00443-1
Abstract: PurposeAlthough EGFR activation is a hallmark of glioblastoma (GBM), anti-EGFR therapy has so far not yielded the desired effects. Targeting PI3K/Akt has been proposed as a strategy to increase the cellular sensitivity to EGFR inhibitors.… read more here.
Keywords: response; gbm; foxo3a; egfr inhibition ... See more keywords
FOXO3a Reverses the Cisplatin Resistance in Ovarian Cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2018.04.014
Abstract: OBJECTIVE Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the… read more here.
Keywords: resistance ovarian; foxo3a; drug; ovarian cancer ... See more keywords
Ellagic acid protects rats from chronic renal failure via MiR-182/FOXO3a axis.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular immunology"
DOI: 10.1016/j.molimm.2021.08.007
Abstract: Studies showed that ellagic acid (EA) can significantly improve kidney function, but the renal-protective effects of EA and the potential mechanism require adequate elucidation. This study investigated the mechanisms of EA in chronic renal failure… read more here.
Keywords: renal failure; foxo3a; mir 182; chronic renal ... See more keywords
IL-1β promotes esophageal squamous cell carcinoma growth and metastasis through FOXO3A by activating the PI3K/AKT pathway
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02008-0
Abstract: Esophageal cancer is a common type of cancer that poses a significant threat to human health. While the pro-inflammatory cytokine IL-1β has been known to contribute to the development of various types of tumors, its… read more here.
Keywords: esophageal squamous; cell; squamous cell; foxo3a ... See more keywords