Circ_0124644 enhances ox-LDL-induced cell damages in human umbilical vein endothelial cells through upregulating FOXO4 by sponging miR-370-3p.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical hemorheology and microcirculation"
DOI: 10.3233/ch-211375
Abstract: BACKGROUND Circular RNA circ_0124644 has crucial regulation in the progression of coronary artery diseases, including atherosclerosis (AS). The aim of this study was to explore the regulatory mechanism of circ_0124644 in oxidized low-density lipoprotein (ox-LDL)-induced… read more here.
Keywords: cell; circ 0124644; mir 370; ldl induced ... See more keywords
Atorvastatin regulates vascular smooth muscle cell phenotypic transformation by epigenetically modulating contractile proteins and mediating Akt/FOXO4 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular medicine reports"
DOI: 10.3892/mmr.2022.12683
Abstract: Atherosclerosis (AS) is a prevalent cardiovascular disease with severe morbidity and high mortality. Phenotypic regulation of vascular smooth muscle cells (VSMCs) from the contractile and quiescent phenotype to the synthetic type is a critical step… read more here.
Keywords: contractile proteins; phenotypic transformation; phenotypic; atorvastatin ... See more keywords
Downregulation of FOXO4 promotes neuronal survival by mediating oxidative-stress–induced apoptosis after cerebral ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v20i1.4
Abstract: Purpose: To investigate the effect of FOXO4 on cerebral ischemia/reperfusion (CIR) injury and the underlying mechanism.Methods: An in vitro ischemia/reperfusion (IR) model was achieved using oxygen-glucose deprivation/reoxygenation (OGD/R). Expression of RNA and protein was determined… read more here.
Keywords: foxo4; ischemia reperfusion; injury; cerebral ischemia ... See more keywords