miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology letters"
DOI: 10.1007/s10529-020-03013-w
Abstract: miRNAs have been pointed to play critical role in the development of congenital heart disease (CHD). miRNA-375-3p (miR-375-3p) was involved in cardiac dysfunction and cardiogenesis. However, no prior study had established a therapeutic role of… read more here.
Keywords: h9c2 cells; apoptosis; bcl2l2; mir 375 ... See more keywords
Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Reports"
DOI: 10.1038/s44319-024-00131-8
Abstract: Neural progenitor cells within the cerebral cortex undergo a characteristic switch between symmetric self-renewing cell divisions early in development and asymmetric neurogenic divisions later. Yet, the mechanisms controlling this transition remain unclear. Previous work has… read more here.
Keywords: loss; angiogenesis; cell; neural progenitor ... See more keywords
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2016046
Abstract: ABSTRACT Forkhead box protein P1 (Foxp1) exerts an extensive array of physiological and pathophysiological impacts on the cardiovascular system. However, the exact function of myocardial Foxp1 in myocardial ischemic reperfusion injury (MIRI) stays largely vague.… read more here.
Keywords: hypoxia reoxygenation; h9c2 cells; pik3ip1; foxp1 ... See more keywords
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac038
Abstract: Abstract Aging poses a major risk factor for cardiovascular diseases, the leading cause of death in the aged population. However, the cell type-specific changes underlying cardiac aging are far from being clear. Here, we performed… read more here.
Keywords: cell; single nucleus; primate cardiac; cardiac aging ... See more keywords
Peli1 Deficiency in Macrophages Attenuates Pulmonary Hypertension by Enhancing Foxp1-Mediated Transcriptional Inhibition of IL-6
Sign Up to like & getrecommendations! Published in 2024 at "Hypertension"
DOI: 10.1161/hypertensionaha.124.23542
Abstract: BACKGROUND: The infiltration of macrophages into the lungs is a common characteristic of perivascular inflammation, contributing to vascular remodeling in pulmonary hypertension (PH). Peli1 (pellino E3 ubiquitin-protein ligase 1) plays a critical role in regulating… read more here.
Keywords: mice; peli1; pulmonary hypertension; hypertension ... See more keywords
Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.12988
Abstract: Background Primary mediastinal large B-cell lymphoma (PMBL) shares pathological features with diffuse large B-cell lymphoma (DLBCL), and molecular features with classical Hodgkin lymphoma (cHL). The miR-17∼92 oncogenic cluster, located at chromosome 13q31, is a region… read more here.
Keywords: regulation; large cell; foxp1; cell ... See more keywords
p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26376
Abstract: B Cell Receptor (BCR) signalling is fundamental for the maturation, survival, and proliferation of B cells, and B cell malignancies frequently harbor mutations in this pathway and/or complex deregulation of interconnected signalling [1]. This is… read more here.
Keywords: bcr; mir 34a; bcr signalling; foxp1 ... See more keywords
Upregulation of FOXP1 is a new independent unfavorable prognosticator and a specific predictor of lymphatic dissemination in cutaneous melanoma patients
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s151286
Abstract: Background FOXP1 is a pleiotropic protein that plays important roles in immune responses (B-cell development regulation and differentiation of monocyte), organ development (cardiac valves, lung, and esophagus), and neuronal development. Besides being the primary regulator… read more here.
Keywords: cutaneous melanoma; foxp1 expression; lymphatic dissemination; foxp1 ... See more keywords
Knockdown of LINC00473 Enhances Radiosensitivity in Hepatocellular Carcinoma via Regulating the miR-345-5p/FOXP1 Axis
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s240113
Abstract: Background Hepatocellular carcinoma (HCC) is the most common form of liver cancer. Radioresistance is a significant obstacle in HCC therapy. Long non-coding RNA 473 (LINC00473) has been found to impair the effect of radiotherapy. This… read more here.
Keywords: radiosensitivity; hepatocellular carcinoma; hcc; foxp1 ... See more keywords
FOXP1 is associated with oncogenesis and clinical outcomes in hematologic malignancies
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1569641
Abstract: Depending on the cellular context and cancer type, FOXP1 functions as an oncogene or a tumor suppressor. However, the clinical role of FOXP1 in hematologic malignancies has not been studied comprehensively. This study systematically analyzed… read more here.
Keywords: foxp1 expression; hematologic malignancies; clinical outcomes; hematological malignancies ... See more keywords
Modulators of Alpha-2 Macroglobulin Upregulation by High Glucose in Glomerular Mesangial Cells
Sign Up to like & getrecommendations! Published in 2024 at "Biomolecules"
DOI: 10.3390/biom14111444
Abstract: Up to 40% of patients with diabetes mellitus will develop diabetic kidney disease (DKD), characterized pathologically by the accumulation of extracellular matrix proteins, which leads to the loss of kidney function over time. Our previous… read more here.
Keywords: mesangial cells; high glucose; alpha macroglobulin; glomerular mesangial ... See more keywords