miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology letters"
DOI: 10.1007/s10529-020-03013-w
Abstract: miRNAs have been pointed to play critical role in the development of congenital heart disease (CHD). miRNA-375-3p (miR-375-3p) was involved in cardiac dysfunction and cardiogenesis. However, no prior study had established a therapeutic role of… read more here.
Keywords: h9c2 cells; apoptosis; bcl2l2; mir 375 ... See more keywords
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2016046
Abstract: ABSTRACT Forkhead box protein P1 (Foxp1) exerts an extensive array of physiological and pathophysiological impacts on the cardiovascular system. However, the exact function of myocardial Foxp1 in myocardial ischemic reperfusion injury (MIRI) stays largely vague.… read more here.
Keywords: hypoxia reoxygenation; h9c2 cells; pik3ip1; foxp1 ... See more keywords
Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging
Sign Up to like & getrecommendations! Published in 2022 at "Protein & Cell"
DOI: 10.1093/procel/pwac038
Abstract: Abstract Aging poses a major risk factor for cardiovascular diseases, the leading cause of death in the aged population. However, the cell type-specific changes underlying cardiac aging are far from being clear. Here, we performed… read more here.
Keywords: cell; single nucleus; primate cardiac; cardiac aging ... See more keywords
Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting
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DOI: 10.18632/oncotarget.12988
Abstract: Background Primary mediastinal large B-cell lymphoma (PMBL) shares pathological features with diffuse large B-cell lymphoma (DLBCL), and molecular features with classical Hodgkin lymphoma (cHL). The miR-17∼92 oncogenic cluster, located at chromosome 13q31, is a region… read more here.
Keywords: regulation; large cell; foxp1; cell ... See more keywords
p53 limits B cell receptor (BCR) signalling: a new role for miR-34a and FOXP1
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26376
Abstract: B Cell Receptor (BCR) signalling is fundamental for the maturation, survival, and proliferation of B cells, and B cell malignancies frequently harbor mutations in this pathway and/or complex deregulation of interconnected signalling [1]. This is… read more here.
Keywords: bcr; mir 34a; bcr signalling; foxp1 ... See more keywords
Upregulation of FOXP1 is a new independent unfavorable prognosticator and a specific predictor of lymphatic dissemination in cutaneous melanoma patients
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s151286
Abstract: Background FOXP1 is a pleiotropic protein that plays important roles in immune responses (B-cell development regulation and differentiation of monocyte), organ development (cardiac valves, lung, and esophagus), and neuronal development. Besides being the primary regulator… read more here.
Keywords: cutaneous melanoma; foxp1 expression; lymphatic dissemination; foxp1 ... See more keywords
Knockdown of LINC00473 Enhances Radiosensitivity in Hepatocellular Carcinoma via Regulating the miR-345-5p/FOXP1 Axis
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DOI: 10.2147/ott.s240113
Abstract: Background Hepatocellular carcinoma (HCC) is the most common form of liver cancer. Radioresistance is a significant obstacle in HCC therapy. Long non-coding RNA 473 (LINC00473) has been found to impair the effect of radiotherapy. This… read more here.
Keywords: radiosensitivity; hepatocellular carcinoma; hcc; foxp1 ... See more keywords
Endothelial Klf2-Foxp1-TGFβ signal mediates the inhibitory effects of simvastatin on maladaptive cardiac remodeling
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DOI: 10.7150/thno.48153
Abstract: Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a… read more here.
Keywords: inhibition; foxp1; cardiac remodeling; maladaptive cardiac ... See more keywords