The evolution of FOXP2 in the light of admixture
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2018.04.006
Abstract: Evolutionary changes in the genomic region of FOXP2 have been studied extensively. The functional consequences of changes in this gene — and larger networks in which it is embedded — might have contributed to human-specific cognitive and behavioral traits.… read more here.
Keywords: admixture; foxp2; foxp2 light; light admixture ... See more keywords
M78 GENES IMPLICATED IN NEURODEVELOPMENT ARE ENRICHED FOR FOXP2 BINDING SITES ASSOCIATED WITH LANGUAGE ABILITY
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.385
Abstract: Background Specific Language Impairment (SLI) is a neurodevelopmental condition which causes linguistic deficits in children with otherwise normal development. SLI is demonstrably heritable (h2 ~ 0.6) and relatively common (occurring in ~7% of the population).… read more here.
Keywords: associated language; foxp2; binding sites; language ability ... See more keywords
FOXP2 Promotes Tumor Proliferation and Metastasis by Targeting GRP78 in Triple-negative Breast Cancer.
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DOI: 10.2174/1568009618666180131115356
Abstract: BACKGROUND FOXP2, a member of the forkhead box P (FOXP) family, has been reported to be important in breast cancer. However, its exact mechanisms and pathways remain unclear. OBJECTIVE To investigate the effect of FOXP2… read more here.
Keywords: foxp2; breast cancer; tnbc; expression ... See more keywords
The FOXP2-Driven Network in Developmental Disorders and Neurodegeneration
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00212
Abstract: The transcription repressor FOXP2 is a crucial player in nervous system evolution and development of humans and songbirds. In order to provide an additional insight into its functional role we compared target gene expression levels… read more here.
Keywords: developmental disorders; foxp2 driven; foxp2; regulation ... See more keywords
Low expression of FOXP2 predicts poor survival and targets caspase-1 to inhibit cell pyroptosis in colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer"
DOI: 10.7150/jca.62433
Abstract: Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Several studies have suggested that FOXP2 functions as a tumour suppressor. However, to date, it remains unclear how FOXP2 influences CRC occurrence. Methods: We… read more here.
Keywords: cancer; expression; cell pyroptosis; cell ... See more keywords