STAT6 controls the stability and suppressive function of regulatory T cells
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250128
Abstract: Signal transducer and activator of transcription 6 (STAT6) promotes tumorigenesis by decreasing the Forkhead box P3+ (Foxp3+) cell frequency allowing for the infiltration of inflammatory cells during the early stages of colitis‐associated cancer (CAC). In… read more here.
Keywords: regulatory cells; stat6 controls; stability suppressive; stat6 ... See more keywords
Reduction of Foxp3+ T cell subsets involved in incidence of chronic graft‐versus‐host disease after allogeneic hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2255
Abstract: Foxp3+ T cells (CD4+ Tregs and CD8+ Treg) have been demonstrated to play roles in the maintenance of tolerance after allogeneic hematopoietic stem cell transplantation (Allo‐HSCT). We have found that Foxp3+ γδTCR+ Treg cells (γδTregs)… read more here.
Keywords: cgvhd; group; allogeneic hematopoietic; foxp3 ... See more keywords
MKL1/miR34a/FOXP3 axis regulates cell proliferation in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28056
Abstract: Megakaryoblastic leukemia 1 (MKL1) was closely related to the pathogenesis of various human malignant cancers. MiR34a was reported to be closely related to cancer cell proliferation. Forkhead box protein 3 (FOXP3) was a transcription factor… read more here.
Keywords: mkl1 mir34a; gastric cancer; cell proliferation; proliferation ... See more keywords
FOXP3+ T cells are present in kidney biopsy samples in children with tubulointerstitial nephritis and uveitis syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Nephrology"
DOI: 10.1007/s00467-017-3796-z
Abstract: BackgroundTubulointerstitial nephritis (TIN) is an inflammatory disease of unknown pathogenesis. To evaluate a possible role of regulatory T cells (Tregs) in the pathophysiology of TIN with (TINU) and without uveitis, we investigated the presence and… read more here.
Keywords: kidney biopsy; present kidney; foxp3 cells; cells present ... See more keywords
Regulatory T Cells: the Many Faces of Foxp3
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Immunology"
DOI: 10.1007/s10875-019-00684-7
Abstract: Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary… read more here.
Keywords: cells many; regulatory cells; foxp3; treg cell ... See more keywords
Analysis of FOXP3+ regulatory T cell subpopulations in peripheral blood and tissue of patients with systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "Immunologic Research"
DOI: 10.1007/s12026-017-8904-4
Abstract: Regulatory T cells (Tregs) are critical mediators of immune tolerance, yet their involvement in the autoimmune disease systemic lupus erythematosus (SLE) is incompletely understood. We analyzed CD4+ T cell subpopulations with Treg-related phenotypes and their… read more here.
Keywords: cd4 cd25; foxp3; cell subpopulations; cell ... See more keywords
Targeting FOXP3 complex ensemble in drug discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in protein chemistry and structural biology"
DOI: 10.1016/bs.apcsb.2019.11.010
Abstract: Forkhead Box P3 (FOXP3) is a key transcriptional regulator of regulatory T cells (Tregs), especially for its function of immune suppression. The special immune suppression function of Tregs plays an important role in maintaining immune… read more here.
Keywords: complex ensemble; ensemble drug; foxp3; drug discovery ... See more keywords
Abnormal acetylation of FOXP3 regulated by SIRT-1 induces Treg functional deficiency in patients with abdominal aortic aneurysms.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.02.001
Abstract: BACKGROUND AND AIMS Acetylation levels of FOXP3 could influence its expression level and SIRT1 is a deacetylase, which could regulate the acetylation level of FOXP3. We aimed to investigate the mechanism of Treg dysfunction, which… read more here.
Keywords: acetylation; aaa patients; foxp3; expression ... See more keywords
Association of FOXP3 and GAGE10 Promoter Polymorphisms and Decreased FOXP3 Expression in Regulatory T cells with Susceptibility to Generalized Vitiligo in Gujarat Population.
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DOI: 10.1016/j.gene.2020.145295
Abstract: Alterations in regulatory T (Treg) cells have been observed in generalized vitiligo (GV) patients and decreased Forkhead Box P3 (FOXP3) has been implicated in the disease pathogenesis. The present study examined FOXP3 rs3761547(A>G), rs3761548(C>A), rs2232365(A>G)… read more here.
Keywords: protein; generalized vitiligo; gujarat population; foxp3 ... See more keywords
FOXP3rs3761548 gene variant and interleukin-35 serum levels as biomarkers in patients with multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2020 at "Revue neurologique"
DOI: 10.1016/j.neurol.2020.07.010
Abstract: BACKGROUND Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). Aberrant expression of transcription factor forkhead box P3 (FoxP3) has been suggested to underlie different immunological disorders as FOXP3 expression… read more here.
Keywords: sclerosis; gene variant; foxp3rs3761548 gene; multiple sclerosis ... See more keywords
Upregulation of FOXP3 is associated with severity of hypoxia and poor outcomes in COVID-19 patients
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DOI: 10.1016/j.virol.2021.08.012
Abstract: The levels of messenger RNA (mRNA) transcription of FOXP3, IFN-γ, TNF, IL-6 and COX-2 from both COVID-19 infected and control subjects were evaluated using SYBRTM green real-time polymerase chain reaction (RT-PCR). Severe/critical cases showed significantly… read more here.
Keywords: covid patients; foxp3; foxp3 associated; upregulation foxp3 ... See more keywords