SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3+ regulatory T cells
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.201948307
Abstract: SOCS3 is a cytosolic inhibitor of cytokine signaling that suppresses the activation of cytokine receptor‐associated JAK kinases. Mechanistically, SOCS3 is recruited to a site in the cytokine receptors known as the SOCS3‐interaction motif, and then… read more here.
Keywords: cytokine; socs3; foxp3 regulatory; cytokine signaling ... See more keywords
Depletion of Foxp3+ regulatory T cells but not the absence of CD19+IL‐10+ regulatory B cells hinders tumor growth in a para‐orthotopic neuroblastoma mouse model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34262
Abstract: Adaptive immune cells with regulatory function reportedly mediate immune escape in a variety of tumors. Little is known regarding the relevance of the most prominent regulatory cell populations, namely Foxp3+ T regulatory cells (Tregs) and… read more here.
Keywords: tumor growth; regulatory cells; foxp3 regulatory; cd19 regulatory ... See more keywords
Monitoring and Modulation of Inducible Foxp3+ Regulatory T-Cell Differentiation in the Lymph Nodes Draining the Small Intestine and Colon.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6786-5_16
Abstract: The mucosa-draining lymphoid tissue favors differentiation of inducible Foxp3+ regulatory T cells. Adoptive transfer of T-cell receptor (TCR) transgenic (Tg) T cells is a powerful tool to study antigen-specific regulatory T-cell differentiation in lymphoid tissues… read more here.
Keywords: lymph nodes; cell differentiation; regulatory cell; foxp3 regulatory ... See more keywords
TNFR2-expressing CD4+Foxp3+ regulatory T cells in cancer immunology and immunotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.03.010
Abstract: CD4+Foxp3+ regulatory T cells (Tregs) represent a major cellular mechanism in tumor immune evasion. Elimination of Treg activity has become a strategy to devise an effective tumor immunotherapy. We reported that TNF receptor type II… read more here.
Keywords: cd4 foxp3; foxp3 regulatory; tnfr2; immunology ... See more keywords
The alarmins IL-1 and IL-33 differentially regulate the functional specialisation of Foxp3+ regulatory T cells during mucosal inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Mucosal Immunology"
DOI: 10.1038/s41385-019-0153-5
Abstract: SummaryCD4+Foxp3+ regulatory T (TREG) cells are critical mediators of peripheral tolerance and modulators of immune responses. Functional adaptation of TREG cells, through acquisition of secondary transcription factors is critical for their effector differentiation towards local… read more here.
Keywords: treg cells; adaptation treg; foxp3 regulatory; cells mucosal ... See more keywords
Progesterone modulates CD4+CD25+FoxP3+ regulatory T Cells and TGF‐β1 in the maternal‐fetal interface of the late pregnant mouse
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Reproductive Immunology"
DOI: 10.1111/aji.13541
Abstract: Progesterone supplementation is recommended to prevent spontaneous preterm birth (sPTB) in clinical practice. However, the exact mechanism is still unclear. This study aims to better understand the mechanisms that progesterone can prevent PTB. read more here.
Keywords: foxp3 regulatory; cd25 foxp3; cd4 cd25; modulates cd4 ... See more keywords
Prognostic value of FOXP3+ regulatory T cells for patients with locally advanced oropharyngeal squamous cell carcinoma
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DOI: 10.1371/journal.pone.0274830
Abstract: Background Oropharyngeal squamous cell carcinoma (OPSCC) is the most common neoplasm originating at the base of the tongue or in the tonsils or soft palate. In this study, we investigated the prognostic value of FOXP3+… read more here.
Keywords: locally advanced; treg; cell; regulatory cells ... See more keywords
Foxp3+ T Regulatory Cells: Still Many Unanswered Questions—A Perspective After 20 Years of Study
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01048
Abstract: T regulatory (Treg) cells were discovered more than 20 years ago and have remained a topic of intense investigation by immunologists. The initial doubts about their existence were dissipated by the discovery in 2003 of the… read more here.
Keywords: suppression; cells still; foxp3 regulatory; regulatory cells ... See more keywords
CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.02901
Abstract: Since their discovery CD4+FOXP3+ regulatory T cells (Tregs) represented a promising tool to induce tolerance in allogeneic hematopoietic cell transplantation. Preclinical models proved that adoptive transfer of Tregs or the use of compounds that can… read more here.
Keywords: hematopoietic transplantation; regulatory cell; foxp3 regulatory; transplantation ... See more keywords
Fast and Efficient Genome Editing of Human FOXP3+ Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.655122
Abstract: FOXP3+ regulatory T cells (Tregs) are central for maintaining peripheral tolerance and immune homeostasis. Because of their immunosuppressive characteristics, Tregs are a potential therapeutic target in various diseases such as autoimmunity, transplantation and infectious diseases… read more here.
Keywords: human tregs; genome editing; editing human; foxp3 regulatory ... See more keywords
A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.703632
Abstract: The Mads/Mef2 (Mef2a/b/c/d) family of transcription factors (TFs) regulates differentiation of muscle cells, neurons and hematopoietic cells. By functioning in physiological feedback loops, Mef2 TFs promote the transcription of their repressor, Hdac9, thereby providing temporal… read more here.
Keywords: mef2d; mef2c; foxp3 regulatory; hdac9 ... See more keywords