Structures of ferroportin in complex with its specific inhibitor vamifeport
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DOI: 10.1101/2022.08.29.505642
Abstract: A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe2+ transport and induces internalization and degradation of FPN. Dysregulation of… read more here.
Keywords: structures ferroportin; iron; fpn; inhibitor vamifeport ... See more keywords
Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells.
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DOI: 10.26355/eurrev_201806_15267
Abstract: OBJECTIVE Ferroptosis is a new-found iron-dependent form of non-apoptotic regulated cell death (RCD), which is activated on therapy with several antitumor agents, but the potential mechanism remains unclear. Erastin, exhibiting selectivity for RAS-mutated cancer cells,… read more here.
Keywords: ferroptosis neuroblastoma; fpn; ferroptosis; iron ... See more keywords
Mechanism of Ca2+ transport by ferroportin
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DOI: 10.7554/elife.82947
Abstract: Ferroportin (Fpn) is a transporter that releases Fe2+ from cells and is important for iron homeostasis in circulation. Export of Fe2+ by Fpn is coupled to import of H+ to maintain charge balance. Although Ca2+… read more here.
Keywords: ferroportin; fpn; ca2 transport; transport ... See more keywords