Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence
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DOI: 10.1186/s12885-020-07039-1
Abstract: Background The oncogene LSF (encoded by TFCP2 ) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular carcinoma and… read more here.
Keywords: lsf; fqi1 sirna; treatment; cancer ... See more keywords