Fra1 Controls Rheumatoid Factor Autoantibody Production by Bone Marrow Plasma Cells and the Development of Autoimmune Bone Loss
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DOI: 10.1002/jbmr.3705
Abstract: Next to proinflammatory cytokines, autoimmunity has been identified as a key trigger for osteoclast activation and bone loss. IgG‐rheumatoid factor (IgG‐RF) immune complexes, which are present in patients with rheumatoid arthritis, were shown to boost… read more here.
Keywords: production; bone; plasma cells; bone loss ... See more keywords
E69K mutation in β-tubulin 2 blocks cell wall integrity signaling during plant cell elongation
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DOI: 10.1038/s44319-025-00507-4
Abstract: The intact cell wall is the prerequisite for plant cell morphogenesis. Loss of function in FRA1/KINESIN-4A, which encodes a microtubule-based kinesin motor, causes dwarfed growth phenotypes with reduced cell wall mechanics. However, the underlying mechanisms… read more here.
Keywords: cell elongation; cell wall; fra1; cell ... See more keywords
The Arabidopsis kinesin-4, FRA1, requires a high level of processive motility to function correctly
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DOI: 10.1242/jcs.196857
Abstract: ABSTRACT Processivity is important for kinesins that mediate intracellular transport. Structure–function analyses of N-terminal kinesins (i.e. kinesins comprising their motor domains at the N-terminus) have identified several non-motor regions that affect processivity in vitro. However,… read more here.
Keywords: processive motility; processivity; function; kinesin ... See more keywords